| Reaction Details |
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 | Report a problem with these data |
| Target | Menin |
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| Ligand | BDBM480343 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Polarization (FP) Competitive Binding Assay |
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| IC50 | 3.00±n/a nM |
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| Citation |  Wang, S; Aguilar, A; Zheng, K; Xu, S; Xu, T; Bernard, D; Huang, L Piperidines as menin inhibitors US Patent US10899738 Publication Date 1/26/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Menin |
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| Name: | Menin |
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| Synonyms: | MEN1 | MEN1_HUMAN | Menin/Histone-lysine N-methyltransferase MLL | SCG2 |
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| Type: | Protein |
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| Mol. Mass.: | 68022.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00255 |
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| Residue: | 610 |
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| Sequence: | MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPE
LTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKK
VSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSED
HAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMV
CAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLT
LYHKGIASAKTYYRDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEI
YKEFFEVANDVIPNLLKEAASLLEAGEERPGEQSQGTQSQGSALQDPECFAHLLRFYDGI
CKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVRIVSREAEAAEAEEPWGEEAREGRR
RGPRRESKPEEPPPPKKPALDKGLGTGQGAVSGPPRKPPGTVAGTARGPEGGSTAQVPAP
TASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTL
SFLKRQRKGL
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| BDBM480343 |
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| n/a |
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| Name | BDBM480343 |
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| Synonyms: | US10899738, Cpd. No 408 | rac-(1S,2R)-2-(1-(1-((1-(4- cyanophenyl)azetidin-3- yl)methyl)piperidin-4-yl)-2- (2-ethyl-1H-imidazol-1-yl)- 1-phenylethyl)cyclopentyl methylcarbamate |
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| Type | Small organic molecule |
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| Emp. Form. | C36H46N6O2 |
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| Mol. Mass. | 594.7894 |
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| SMILES | CCc1nccn1CC([C@H]1CCC[C@@H]1OC(=O)NC)(C1CCN(CC2CN(C2)c2ccc(cc2)C#N)CC1)c1ccccc1 |r| |
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| Structure | 
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