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TargetEndothelin-1
LigandBDBM172825
Substrate/Competitorn/a
Meas. Tech.ET-1 Assay
EC50<50000±n/a nM
Citation PubChem PCBuckman BONicholas JBRamphal JYEmayan KSeiwert SD Anti-fibrotic pyridinones US Patent  US9675593 Publication Date 6/13/2017
More Info.:Get all data from this article,  Assay Method
 
Endothelin-1
Name:Endothelin-1
Synonyms:PPET1 | Preproendothelin-1
Type:Protein
Mol. Mass.:24444.51
Organism:Homo sapiens (Human)
Description:P05305
Residue:212
Sequence:
MDYLLMIFSLLFVACQGAPETAVLGAELSAVGENGGEKPTPSPPWRLRRSKRCSCSSLMD
KECVYFCHLDIIWVNTPEHVVPYGLGSPRSKRALENLLPTKATDRENRCQCASQKDKKCW
NFCQAGKELRAEDIMEKDWNNHKKGKDCSKLGKKCIYQQLVRGRKIRRSSEEHLRQTRSE
TMRNSVKSSFHDPKLKGKPSRERYVTHNRAHW
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM172825
n/a
NameBDBM172825
Synonyms:US9675593, 690
TypeSmall organic molecule
Emp. Form.C23H23F3N4O4
Mol. Mass.476.4483
SMILESCn1cc(cn1)-c1cn(-c2ccc(OC(F)(F)F)cc2)c(=O)c2N(CCc12)C(=O)OC(C)(C)C
Structure
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