Ki Summary

Reaction Details

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Target

Activin receptor type-1 [172-499]

Ligand

BDBM451794

Substrate/Competitor

n/a

Meas. Tech.

Caliper Assay

IC50

18.0±n/a nM

Citation

Arista, L; Babu, S; Bian, J; Cui, K; Dillon, MP; Lattmann, R; Li, J; Liao, L; Lizos, D; Ramos, R; Stiefl, NJ; Ullrich, T; Usselmann, P; Wang, X; Waykole, LM; Weiler, S; Zhang, Y; Zhou, Y; Zhu, T Aminopyridine derivatives and their use as selective ALK-2 inhibitors US Patent US10947218 Publication Date 3/16/2021

More Info.:

Get all data from this article, Assay Method

Activin receptor type-1 [172-499]

Name:

Activin receptor type-1 [172-499]

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

37139.64

Organism:

Homo sapiens (Human)

Description:

aa 172-499

Residue:

328

Sequence:

TTNVGDSTLADLLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGEN
VAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSL
YDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKPAIAHRDLKSKNILVKKNGQCC
IADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVL
WEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLA
KLMKECWYQNPSARLTALRIKKTLTKID

BDBM451794

n/a

Name

BDBM451794

Synonyms:

US10710980, Example 26 | US10947218, Example 26

Type

Small organic molecule

Emp. Form.

C26H32N4O3

Mol. Mass.

448.5573

SMILES

Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(C2)C1COC1 |r,wU:25.27,10.10,wD:23.25,13.14,(-3.56,5.32,;-2.22,4.55,;-.89,5.32,;.44,4.55,;.44,3.01,;-.89,2.24,;-2.22,3.01,;-3.56,2.24,;-4.89,3.01,;-3.56,.7,;-5.05,.3,;-5.44,-1.19,;-6.93,-1.59,;-8.02,-.5,;-9.51,-.9,;-7.62,.99,;-6.13,1.39,;1.78,2.24,;1.78,.7,;3.11,-.07,;4.44,.7,;4.44,2.24,;3.11,3.01,;5.78,-.07,;5.94,1.46,;7.18,.56,;8.21,-.59,;7.44,-1.92,;5.94,-1.6,;8.07,-3.33,;7.52,-4.77,;8.96,-5.32,;9.51,-3.88,)|

Structure