Reaction Details | |||
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Target | Bone morphogenetic protein receptor type-1B | ||
Ligand | BDBM451794 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Caliper Assay | ||
IC50 | 2500±n/a nM | ||
Citation | Arista, L; Babu, S; Bian, J; Cui, K; Dillon, MP; Lattmann, R; Li, J; Liao, L; Lizos, D; Ramos, R; Stiefl, NJ; Ullrich, T; Usselmann, P; Wang, X; Waykole, LM; Weiler, S; Zhang, Y; Zhou, Y; Zhu, T Aminopyridine derivatives and their use as selective ALK-2 inhibitors US Patent US10947218 Publication Date 3/16/2021 | ||
More Info.: | Get all data from this article, Assay Method | ||
Bone morphogenetic protein receptor type-1B | |||
Name: | Bone morphogenetic protein receptor type-1B | ||
Synonyms: | ALK-6 | ALK6 | BMPR1B | BMR1B_HUMAN | Bone morphogenetic protein receptor type-1B (BMPR1B) | ||
Type: | Enzyme | ||
Mol. Mass.: | 56939.41 | ||
Organism: | Homo sapiens (Human) | ||
Description: | O00238 | ||
Residue: | 502 | ||
Sequence: |
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BDBM451794 | |||
n/a | |||
Name | BDBM451794 | ||
Synonyms: | US10710980, Example 26 | US10947218, Example 26 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H32N4O3 | ||
Mol. Mass. | 448.5573 | ||
SMILES | Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(C2)C1COC1 |r,wU:25.27,10.10,wD:23.25,13.14,(-3.56,5.32,;-2.22,4.55,;-.89,5.32,;.44,4.55,;.44,3.01,;-.89,2.24,;-2.22,3.01,;-3.56,2.24,;-4.89,3.01,;-3.56,.7,;-5.05,.3,;-5.44,-1.19,;-6.93,-1.59,;-8.02,-.5,;-9.51,-.9,;-7.62,.99,;-6.13,1.39,;1.78,2.24,;1.78,.7,;3.11,-.07,;4.44,.7,;4.44,2.24,;3.11,3.01,;5.78,-.07,;5.94,1.46,;7.18,.56,;8.21,-.59,;7.44,-1.92,;5.94,-1.6,;8.07,-3.33,;7.52,-4.77,;8.96,-5.32,;9.51,-3.88,)| | ||
Structure |