Ki Summary

Reaction Details

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Target

TGF-beta receptor type-1 [162-503]

Ligand

BDBM451795

Substrate/Competitor

n/a

Meas. Tech.

Caliper Assay

IC50

1300±n/a nM

Citation

Arista, L; Babu, S; Bian, J; Cui, K; Dillon, MP; Lattmann, R; Li, J; Liao, L; Lizos, D; Ramos, R; Stiefl, NJ; Ullrich, T; Usselmann, P; Wang, X; Waykole, LM; Weiler, S; Zhang, Y; Zhou, Y; Zhu, T Aminopyridine derivatives and their use as selective ALK-2 inhibitors US Patent US10947218 Publication Date 3/16/2021

More Info.:

Get all data from this article, Assay Method

TGF-beta receptor type-1 [162-503]

Name:

TGF-beta receptor type-1 [162-503]

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

38872.23

Organism:

Homo sapiens (Human)

Description:

aa 162-503

Residue:

342

Sequence:

EDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWR
GKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSD
YHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILV
KKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADI
YAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSC
EALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM

BDBM451795

n/a

Name

BDBM451795

Synonyms:

US10710980, Example 27 | US10947218, Example 27

Type

Small organic molecule

Emp. Form.

C29H36F2N4O2

Mol. Mass.

510.6185

SMILES

Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(C2)C1CCC(F)(F)CC1 |r,wU:25.27,10.10,wD:23.25,13.14,(-4.21,6.43,;-2.88,5.66,;-1.54,6.43,;-.21,5.66,;-.21,4.12,;-1.54,3.35,;-2.88,4.12,;-4.21,3.35,;-5.54,4.12,;-4.21,1.81,;-5.7,1.42,;-6.1,-.07,;-7.58,-.47,;-8.67,.62,;-10.16,.22,;-8.27,2.11,;-6.79,2.5,;1.12,3.35,;1.12,1.81,;2.46,1.04,;3.79,1.81,;3.79,3.35,;2.46,4.12,;5.13,1.04,;5.29,2.58,;6.53,1.67,;7.56,.53,;6.79,-.81,;5.29,-.49,;7.42,-2.21,;6.51,-3.46,;7.14,-4.87,;8.67,-5.03,;9.3,-6.43,;10.16,-5.43,;9.58,-3.78,;8.95,-2.37,)|

Structure