Ki Summary

Reaction Details

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Target

TGF-beta receptor type-1 [162-503]

Ligand

BDBM451822

Substrate/Competitor

n/a

Meas. Tech.

Caliper Assay

IC50

1400±n/a nM

Citation

Arista, L; Babu, S; Bian, J; Cui, K; Dillon, MP; Lattmann, R; Li, J; Liao, L; Lizos, D; Ramos, R; Stiefl, NJ; Ullrich, T; Usselmann, P; Wang, X; Waykole, LM; Weiler, S; Zhang, Y; Zhou, Y; Zhu, T Aminopyridine derivatives and their use as selective ALK-2 inhibitors US Patent US10947218 Publication Date 3/16/2021

More Info.:

Get all data from this article, Assay Method

TGF-beta receptor type-1 [162-503]

Name:

TGF-beta receptor type-1 [162-503]

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

38872.23

Organism:

Homo sapiens (Human)

Description:

aa 162-503

Residue:

342

Sequence:

EDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWR
GKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSD
YHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILV
KKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADI
YAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSC
EALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM

BDBM451822

n/a

Name

BDBM451822

Synonyms:

US10710980, Example 51 | US10947218, Example 51

Type

Small organic molecule

Emp. Form.

C26H31N5O2

Mol. Mass.

445.5566

SMILES

Nc1ncc(cc1C(=O)N[C@H]1CC[C@H](O)CC1)-c1ccc(cc1)[C@]12C[C@H]1CN(CCC#N)C2 |r,wU:10.10,25.27,wD:23.25,13.14,(-4.72,5.67,;-3.39,4.9,;-2.05,5.67,;-.72,4.9,;-.72,3.36,;-2.05,2.59,;-3.39,3.36,;-4.72,2.59,;-6.06,3.36,;-4.72,1.05,;-6.06,.28,;-6.19,-1.26,;-7.59,-1.91,;-8.85,-1.03,;-10.07,-1.64,;-8.71,.51,;-7.32,1.16,;.61,2.59,;.61,1.05,;1.95,.28,;3.28,1.05,;3.28,2.59,;1.95,3.36,;4.61,.28,;4.77,1.81,;6.02,.9,;7.05,-.24,;6.28,-1.58,;7.05,-2.91,;8.48,-2.91,;9.25,-4.24,;10.07,-5.67,;4.77,-1.26,)|

Structure