| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase |
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| Ligand | BDBM489196 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Assay |
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| IC50 | 17.5±n/a nM |
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| Citation |  Osborne, S; Large, J Oxazole derivatives for use in the treatment of cancer US Patent US10961233 Publication Date 3/30/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase |
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| Name: | Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase |
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| Synonyms: | ADE2 | AIRC | Multifunctional protein ADE2 | PAICS | PAIS | PUR6_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 47081.21 |
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| Organism: | Human |
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| Description: | P22234 |
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| Residue: | 425 |
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| Sequence: | MATAEVLNIGKKLYEGKTKEVYELLDSPGKVLLQSKDQITAGNAARKNHLEGKAAISNKI
TSCIFQLLQEAGIKTAFTRKCGETAFIAPQCEMIPIEWVCRRIATGSFLKRNPGVKEGYK
FYPPKVELFFKDDANNDPQWSEEQLIAAKFCFAGLLIGQTEVDIMSHATQAIFEILEKSW
LPQNCTLVDMKIEFGVDVTTKEIVLADVIDNDSWRLWPSGDRSQQKDKQSYRDLKEVTPE
GLQMVKKNFEWVAERVELLLKSESQCRVVVLMGSTSDLGHCEKIKKACGNFGIPCELRVT
SAHKGPDETLRIKAEYEGDGIPTVFVAVAGRSNGLGPVMSGNTAYPVISCPPLTPDWGVQ
DVWSSLRLPSGLGCSTVLSPEGSAQFAAQIFGLSNHLVWSKLRASILNTWISLKQADKKI
RECNL
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| BDBM489196 |
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| n/a |
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| Name | BDBM489196 |
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| Synonyms: | US10961233, Example 45 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H23BrN6O3 |
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| Mol. Mass. | 451.318 |
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| SMILES | CN(C)CCN1CCN(CC1=O)c1cccc(Br)c1NC(=O)c1coc(N)n1 |
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| Structure | 
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