| Reaction Details |
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 | Report a problem with these data |
| Target | Stimulator of interferon genes protein [H232R] |
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| Ligand | BDBM490770 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Surface Plasmon Resonance (SPR) Binding |
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| Kd | 116±n/a nM |
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| Citation |  Wythes, MJ; McAlpine, IJ; Patman, R; Rui, EY; Maderna, A; Jalaie, M; Gajiwala, KS Cyclopentane-based modulators of STING (stimulator of interferon genes) US Patent US10968242 Publication Date 4/6/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Stimulator of interferon genes protein [H232R] |
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| Name: | Stimulator of interferon genes protein [H232R] |
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| Synonyms: | ERIS | MITA | STING | STING1 | STING_HUMAN | Stimulator of interferon genes protein STING (H232R) | TMEM173 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 42215.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 379 |
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| Sequence: | MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLL
NGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWM
LALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIR
TYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDRAGIKDRVY
SNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILA
DAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQE
PELLISGMEKPLPLRTDFS
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| BDBM490770 |
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| n/a |
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| Name | BDBM490770 |
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| Synonyms: | US10968242, Example 2 Peak 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24FN9O9P2S2 |
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| Mol. Mass. | 691.546 |
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| SMILES | Cn1cnc2n(cnc2c1=O)[C@@H]1C[C@@H]2OP(S)(=O)O[C@@H]3[C@@H](COP(S)(=O)O[C@@H]1[C@@H]2O)O[C@H]([C@@H]3F)n1cnc2c(N)ncnc12 |r| |
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| Structure | 
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