| Reaction Details |
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 | Report a problem with these data |
| Target | Stimulator of interferon genes protein |
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| Ligand | BDBM490774 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Radioligand Binding Assay |
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| Ki | 4.00±n/a nM |
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| Citation |  Wythes, MJ; McAlpine, IJ; Patman, R; Rui, EY; Maderna, A; Jalaie, M; Gajiwala, KS Cyclopentane-based modulators of STING (stimulator of interferon genes) US Patent US10968242 Publication Date 4/6/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Stimulator of interferon genes protein |
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| Name: | Stimulator of interferon genes protein |
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| Synonyms: | ERIS | Endoplasmic reticulum interferon stimulator | MITA | Mediator of IRF3 activation | STING | STING1 | STING_HUMAN | Synonyms=ERIS | TMEM173 | Transmembrane protein 173 | hMITA | hSTING |
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| Type: | Protein |
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| Mol. Mass.: | 42195.64 |
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| Organism: | Human |
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| Description: | Q86WV6 |
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| Residue: | 379 |
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| Sequence: | MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLL
NGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWM
LALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIR
TYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVY
SNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILA
DAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQE
PELLISGMEKPLPLRTDFS
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| BDBM490774 |
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| n/a |
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| Name | BDBM490774 |
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| Synonyms: | US10968242, Example 3 Peak 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22FN9O9P2S2 |
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| Mol. Mass. | 677.52 |
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| SMILES | Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]2COP(S)(=O)O[C@@H]3[C@H](O)[C@H](C[C@H]3n3cnc4c3nc[nH]c4=O)OP(S)(=O)O[C@H]2[C@H]1F |r| |
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| Structure | 
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