| Reaction Details |
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 | Report a problem with these data |
| Target | Stimulator of interferon genes protein |
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| Ligand | BDBM490801 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Radioligand Binding Assay |
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| Ki | 1260±n/a nM |
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| Citation |  Wythes, MJ; McAlpine, IJ; Patman, R; Rui, EY; Maderna, A; Jalaie, M; Gajiwala, KS Cyclopentane-based modulators of STING (stimulator of interferon genes) US Patent US10968242 Publication Date 4/6/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Stimulator of interferon genes protein |
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| Name: | Stimulator of interferon genes protein |
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| Synonyms: | ERIS | Endoplasmic reticulum interferon stimulator | MITA | Mediator of IRF3 activation | STING | STING1 | STING_HUMAN | Synonyms=ERIS | TMEM173 | Transmembrane protein 173 | hMITA | hSTING |
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| Type: | Protein |
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| Mol. Mass.: | 42195.64 |
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| Organism: | Human |
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| Description: | Q86WV6 |
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| Residue: | 379 |
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| Sequence: | MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLL
NGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWM
LALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIR
TYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVY
SNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILA
DAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQE
PELLISGMEKPLPLRTDFS
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| BDBM490801 |
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| n/a |
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| Name | BDBM490801 |
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| Synonyms: | (4S,6R,7S,11aR,13R,14R,14aR,15R)-6,13-bis(6-amino-9H-purin-9-yl)-14-fluoro-2,9,15-trihydroxyoctahydro-11H-4,7-methanofuro[3,2-d][1,3,7,9]tetraoxa[2,8]diphosphacyclotridecine 2,9-dioxide | US10968242, Example 23 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H23FN10O10P2 |
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| Mol. Mass. | 644.4035 |
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| SMILES | Nc1ncnc2n(cnc12)[C@@H]1C[C@@H]2OP(O)(=O)O[C@@H]3[C@@H](COP(O)(=O)O[C@@H]1[C@@H]2O)O[C@H]([C@@H]3F)n1cnc2c(N)ncnc12 |r| |
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| Structure | 
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