| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-lysine 6-oxidase |
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| Ligand | BDBM469038 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | LOX Enzyme Activity Assay |
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| IC50 | 1100±n/a nM |
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| Citation |  Springer, C; Marais, R; Niculescu-Duvaz, D; Leung, L; Smithen, D; Callens, C; Tang, H Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer US Patent US10995088 Publication Date 5/4/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein-lysine 6-oxidase |
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| Name: | Protein-lysine 6-oxidase |
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| Synonyms: | LOX | LYOX_HUMAN | Lysyl oxidase | alpha-Glucosidase (alpha-Glu) |
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| Type: | PROTEIN |
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| Mol. Mass.: | 46954.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_306619 |
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| Residue: | 417 |
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| Sequence: | MRFAWTVLLLGPLQLCALVHCAPPAAGQQQPPREPPAAPGAWRQQIQWENNGQVFSLLSL
GSQYQPQRRRDPGAAVPGAANASAQQPRTPILLIRDNRTAAARTRTAGSSGVTAGRPRPT
ARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPPSRVDGMVGDDPYNPYKYSDD
NPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAA
EENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDE
FSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADID
CQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY
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| BDBM469038 |
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| n/a |
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| Name | BDBM469038 |
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| Synonyms: | US10807974, Example 47 | US10995088, Example 47 | US11608330, Example 47 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H17F3N2O4S3 |
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| Mol. Mass. | 454.507 |
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| SMILES | NCc1ccc(s1)S(=O)(=O)c1cc(cc(c1)S(=O)(=O)N1CCCC1)C(F)(F)F |
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| Structure | 
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