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TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C]
LigandBDBM497348
Substrate/Competitorn/a
Meas. Tech.Biochemical Assay
IC50<5.08±n/a nM
Citation Bauer, RA; Boulet, SL; Burkholder, TP; Hahn, PJ; Rankovic, Z 7-phenylethylamino-4H-pyrimido[4,5-d][1,3]oxazin-2-one compounds as mutant IDH1 and IDH2 inhibitors US Patent US11001596 Publication Date 5/11/2021
More Info.:Get all data from this article,  Assay Method
 
Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]
Name:Isocitrate dehydrogenase [NADP] cytoplasmic [R132C]
Synonyms:IDH1 | IDH1 R132C | IDH1(R132C) | IDHC_HUMAN | Isocitrate dehydrogenase (IDH1)(R132C) | Isocitrate dehydrogenase 1 mutant (R132C) | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) (R132C) | PICD
Type:Enzyme Catalytic Domain
Mol. Mass.:46607.23
Organism:Homo sapiens (Human)
Description:O75874[R132C]
Residue:414
Sequence:
MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDA
AEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRL
VSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAM
GMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFE
AQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDG
KTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALE
EVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
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  Blast E-value cutoff:
BDBM497348
n/a
NameBDBM497348
Synonyms:1-Ethyl-7-[[(1S)-1-[4-[3- methyl-1-(4-prop-2- enoylpiperazin-1- yl)butyl]phenyl]ethyl]amino]- 4H-pyrimido[4,5- d][1,3]oxazin-2-one | US11001596, Example 6 | US11001596, Example 7 | US11001596, Example 8 | US11629156, Example 6 | US11649247, Example 8
TypeSmall organic molecule
Emp. Form.C28H38N6O3
Mol. Mass.506.6397
SMILESCCN1C(=O)OCc2cnc(N[C@@H](C)c3ccc(cc3)C(CC(C)C)N3CCN(CC3)C(=O)C=C)nc12 |r|
Structure
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