| Reaction Details |
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 | Report a problem with these data |
| Target | Serine protease HTRA1 |
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| Ligand | BDBM499264 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| IC50 | 0.602±n/a nM |
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| Citation |  Hornsperger, B; Iacone, R; Maerki, HP; Mohr, P; Reutlinger, M Trifluoromethylpropanamide derivatives as HTRA1 inhibitors US Patent US11014963 Publication Date 5/25/2021 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine protease HTRA1 |
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| Name: | Serine protease HTRA1 |
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| Synonyms: | HTRA | HTRA1 | HTRA1_HUMAN | PRSS11 |
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| Type: | Protein |
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| Mol. Mass.: | 51293.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92743 |
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| Residue: | 480 |
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| Sequence: | MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARD
ACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCG
SDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIA
PAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEA
KIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTT
QRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKI
KKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPD
TPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP
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| BDBM499264 |
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| n/a |
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| Name | BDBM499264 |
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| Synonyms: | US11014963, Example 163 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H42ClF3N4O7 |
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| Mol. Mass. | 699.157 |
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| SMILES | COc1ccc(cc1)[C@H](NC(=O)[C@H](CCCCNC(=O)OC(C)(C)C)NC(=O)c1cccc(Cl)c1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F |
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| Structure | 
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