Ki Summary

Reaction Details

Report a problem with these data

Target

Mitogen-activated protein kinase kinase kinase 5

Ligand

BDBM503677

Substrate/Competitor

n/a

Meas. Tech.

Biochemical Assay

<100±n/a nM

Citation

Jin, B; Dong, Q; Hung, G Apoptosis signal-regulating kinase inhibitors and uses thereof US Patent US11034671 Publication Date 6/15/2021

More Info.:

Get all data from this article, Assay Method

Mitogen-activated protein kinase kinase kinase 5

Name:

Mitogen-activated protein kinase kinase kinase 5

Synonyms:

ASK1 | M3K5_HUMAN | MAP3K5 | MAPKKK5 | MEKK5

Type:

Protein

Mol. Mass.:

154514.93

Organism:

Homo sapiens (Human)

Description:

Q99683

Residue:

1374

Sequence:

MSTEADEGITFSVPPFAPSGFCTIPEGGICRRGGAAAVGEGEEHQLPPPPPGSFWNVESA
AAPGIGCPAATSSSSATRGRGSSVGGGSRRTTVAYVINEASQGQLVVAESEALQSLREAC
ETVGATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFSMANN
IILYCDTNSDSLQSLKEIICQKNTMCTGNYTFVPYMITPHNKVYCCDSSFMKGLTELMQP
NFELLLGPICLPLVDRFIQLLKVAQASSSQYFRESILNDIRKARNLYTGKELAAELARIR
QRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKFHYAFALN
RRNLPGDRAKALDIMIPMVQSEGQVASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFK
KAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGF
FLGASVLANDHMRVIQASEKLFKLKTPAWYLKSIVETILIYKHFVKLTTEQPVAKQELVD
FWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLPDDKKGIH
EWNFSASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKKFFEMVNTITEEKGRS
TEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQ
PLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTI
GFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFT
GTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVH
PEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSALSAGSNE
YLRSISLPVPVLVEDTSSSSEYGSVSPDTELKVDPFSFKTRAKSCGERDVKGIRTLFLGI
PDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKIVRNLMESLAQGAEEP
KLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNK
VLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADQEDLDVEDDHEE
QPSNQTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLNVQLGRMKIETNRLLEELV
RKEKELQALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLNSSGTNTEDSELTDWLRVN
GADEDTISRFLAEDYTLLDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKQT

BDBM503677

n/a

Name

BDBM503677

Synonyms:

US11034671, Example 69

Type

Small organic molecule

Emp. Form.

C25H22N6O2

Mol. Mass.

438.4812

SMILES

Cc1ccc(cn1)-c1ccc2OCC3C[C@@H](C3)n3cnnc3-c3cccc(NC(=O)c2c1)n3 |r,wU:15.15,(-9.19,3.24,;-7.85,2.47,;-7.85,.93,;-6.52,.16,;-5.19,.93,;-5.19,2.47,;-6.52,3.24,;-3.85,.16,;-3.85,-1.38,;-2.52,-2.15,;-1.18,-1.38,;.15,-2.15,;1.48,-1.38,;2.82,-2.15,;3.91,-3.24,;4.99,-2.15,;3.91,-1.06,;6.82,-1.38,;8.28,-1.86,;9.19,-.61,;8.28,.64,;6.82,.16,;5.48,.93,;5.48,2.47,;4.15,3.24,;2.82,2.47,;2.82,.93,;1.48,.16,;.15,.93,;.15,2.47,;-1.18,.16,;-2.52,.93,;4.15,.16,)|

Structure