Ki Summary

Reaction Details

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Target

Mitogen-activated protein kinase kinase kinase 5

Ligand

BDBM503679

Substrate/Competitor

n/a

Meas. Tech.

Biochemical Assay

<100±n/a nM

Citation

Jin, B; Dong, Q; Hung, G Apoptosis signal-regulating kinase inhibitors and uses thereof US Patent US11034671 Publication Date 6/15/2021

More Info.:

Get all data from this article, Assay Method

Mitogen-activated protein kinase kinase kinase 5

Name:

Mitogen-activated protein kinase kinase kinase 5

Synonyms:

ASK1 | M3K5_HUMAN | MAP3K5 | MAPKKK5 | MEKK5

Type:

Protein

Mol. Mass.:

154514.93

Organism:

Homo sapiens (Human)

Description:

Q99683

Residue:

1374

Sequence:

MSTEADEGITFSVPPFAPSGFCTIPEGGICRRGGAAAVGEGEEHQLPPPPPGSFWNVESA
AAPGIGCPAATSSSSATRGRGSSVGGGSRRTTVAYVINEASQGQLVVAESEALQSLREAC
ETVGATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFSMANN
IILYCDTNSDSLQSLKEIICQKNTMCTGNYTFVPYMITPHNKVYCCDSSFMKGLTELMQP
NFELLLGPICLPLVDRFIQLLKVAQASSSQYFRESILNDIRKARNLYTGKELAAELARIR
QRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKFHYAFALN
RRNLPGDRAKALDIMIPMVQSEGQVASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFK
KAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGF
FLGASVLANDHMRVIQASEKLFKLKTPAWYLKSIVETILIYKHFVKLTTEQPVAKQELVD
FWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLPDDKKGIH
EWNFSASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKKFFEMVNTITEEKGRS
TEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQ
PLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTI
GFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFT
GTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVH
PEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSALSAGSNE
YLRSISLPVPVLVEDTSSSSEYGSVSPDTELKVDPFSFKTRAKSCGERDVKGIRTLFLGI
PDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKIVRNLMESLAQGAEEP
KLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNK
VLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADQEDLDVEDDHEE
QPSNQTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLNVQLGRMKIETNRLLEELV
RKEKELQALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLNSSGTNTEDSELTDWLRVN
GADEDTISRFLAEDYTLLDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKQT

BDBM503679

n/a

Name

BDBM503679

Synonyms:

US11034671, Example 71

Type

Small organic molecule

Emp. Form.

C26H24N6O2

Mol. Mass.

452.5078

SMILES

Cc1ccc(cn1)-c1ccc2OC3CC[C@@H](CC3)n3cnnc3-c3cccc(NC(=O)c2c1)n3 |r,wU:15.19,(-8.52,1.54,;-7.19,.77,;-7.19,-.77,;-5.85,-1.54,;-4.52,-.77,;-4.52,.77,;-5.85,1.54,;-3.19,-1.54,;-3.19,-3.08,;-1.85,-3.85,;-.52,-3.08,;.82,-3.85,;2.15,-3.08,;3.48,-3.85,;4.82,-3.08,;4.82,-1.54,;3.48,-.77,;2.15,-1.54,;6.15,-.77,;7.61,-1.25,;8.52,,;7.61,1.25,;6.15,.77,;4.82,1.54,;4.82,3.08,;3.48,3.85,;2.15,3.08,;2.15,1.54,;.82,.77,;.82,-.77,;2.36,-.77,;-.52,-1.54,;-1.85,-.77,;3.48,.77,)|

Structure