Ki Summary

Reaction Details

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Target

Mitogen-activated protein kinase kinase kinase 5

Ligand

BDBM503691

Substrate/Competitor

n/a

Meas. Tech.

Biochemical Assay

<100±n/a nM

Citation

Jin, B; Dong, Q; Hung, G Apoptosis signal-regulating kinase inhibitors and uses thereof US Patent US11034671 Publication Date 6/15/2021

More Info.:

Get all data from this article, Assay Method

Mitogen-activated protein kinase kinase kinase 5

Name:

Mitogen-activated protein kinase kinase kinase 5

Synonyms:

ASK1 | M3K5_HUMAN | MAP3K5 | MAPKKK5 | MEKK5

Type:

Protein

Mol. Mass.:

154514.93

Organism:

Homo sapiens (Human)

Description:

Q99683

Residue:

1374

Sequence:

MSTEADEGITFSVPPFAPSGFCTIPEGGICRRGGAAAVGEGEEHQLPPPPPGSFWNVESA
AAPGIGCPAATSSSSATRGRGSSVGGGSRRTTVAYVINEASQGQLVVAESEALQSLREAC
ETVGATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFSMANN
IILYCDTNSDSLQSLKEIICQKNTMCTGNYTFVPYMITPHNKVYCCDSSFMKGLTELMQP
NFELLLGPICLPLVDRFIQLLKVAQASSSQYFRESILNDIRKARNLYTGKELAAELARIR
QRVDNIEVLTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKFHYAFALN
RRNLPGDRAKALDIMIPMVQSEGQVASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFK
KAFESEPTLQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGF
FLGASVLANDHMRVIQASEKLFKLKTPAWYLKSIVETILIYKHFVKLTTEQPVAKQELVD
FWMDFLVEATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLPDDKKGIH
EWNFSASSVRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKKFFEMVNTITEEKGRS
TEEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQ
PLHEEIALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTI
GFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFT
GTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVH
PEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLKVSSKKKKTQPKLSALSAGSNE
YLRSISLPVPVLVEDTSSSSEYGSVSPDTELKVDPFSFKTRAKSCGERDVKGIRTLFLGI
PDENFEDHSAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKIVRNLMESLAQGAEEP
KLKWEHITTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNK
VLRNHNIKPHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADQEDLDVEDDHEE
QPSNQTVRRPQAVIEDAVATSGVSTLSSTVSHDSQSAHRSLNVQLGRMKIETNRLLEELV
RKEKELQALLHRAIEEKDQEIKHLKLKSQPIEIPELPVFHLNSSGTNTEDSELTDWLRVN
GADEDTISRFLAEDYTLLDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNKQT

BDBM503691

n/a

Name

BDBM503691

Synonyms:

US11034671, Example 84

Type

Small organic molecule

Emp. Form.

C26H22F2N6O2

Mol. Mass.

488.4887

SMILES

FC(F)c1ccc(cn1)-c1ccc2OC3CC[C@@H](CC3)n3cnnc3-c3cccc(NC(=O)c2c1)n3 |r,wU:17.21,(-9.19,.77,;-7.85,1.54,;-7.85,3.08,;-6.52,.77,;-6.52,-.77,;-5.19,-1.54,;-3.85,-.77,;-3.85,.77,;-5.19,1.54,;-2.52,-1.54,;-2.52,-3.08,;-1.18,-3.85,;.15,-3.08,;1.48,-3.85,;2.82,-3.08,;4.15,-3.85,;5.48,-3.08,;5.48,-1.54,;4.15,-.77,;2.82,-1.54,;6.82,-.77,;8.28,-1.25,;9.19,,;8.28,1.25,;6.82,.77,;5.48,1.54,;5.48,3.08,;4.15,3.85,;2.82,3.08,;2.82,1.54,;1.48,.77,;1.48,-.77,;3.02,-.77,;.15,-1.54,;-1.18,-.77,;4.15,.77,)|

Structure