| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium channel subfamily K member 3 |
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| Ligand | BDBM179659 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Activity Assay |
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| IC50 | 114±n/a nM |
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| Citation |  Bialy, L; Lorenz, K; Wirth, K; Steinmeyer, K; Hessler, G; Pernerstorfer, J; Brendel, J Substituted 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-C]pyridines, their use as medicament, and pharmaceutical preparations comprising them US Patent US9598410 Publication Date 3/21/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium channel subfamily K member 3 |
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| Name: | Potassium channel subfamily K member 3 |
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| Synonyms: | Acid-sensitive potassium channel TASK-1 | Acid-sensitive potassium channel protein TASK-1 | KCNK3 | KCNK3_HUMAN | Potassium channel protein TASK-1 | Potassium channel subfamily K member 3 | Potassium channel subfamily K member 3 (TASK-1) | TASK | TASK1 | TWIK-related acid-sensitive K(+) channel 1 | Two pore K(+) channel KT3.1 | Two pore potassium channel KT3.1 |
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| Type: | Protein |
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| Mol. Mass.: | 43534.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O14649 |
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| Residue: | 394 |
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| Sequence: | MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRARYNLSQGGYE
ELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPL
TLVMFQSLGERINTLVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSH
YEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLN
LVVLRFMTMNAEDEKRDAEHRALLTRNGQAGGGGGGGSAHTTDTASSTAAAGGGGFRNVY
AEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSHSSPGGGGRYSDTPSRR
CLCSGAPRSAISSVSTGLHSLSTFRGLMKRRSSV
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| BDBM179659 |
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| n/a |
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| Name | BDBM179659 |
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| Synonyms: | US9127001, 6am | US9598410, Compound 6am |
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| Type | Small organic molecule |
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| Emp. Form. | C23H19F3N4O |
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| Mol. Mass. | 424.4184 |
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| SMILES | CC(=O)N1CCc2c(C1)c(nn2Cc1ccc(cc1)C#N)-c1cccc(c1)C(F)(F)F |
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| Structure | 
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