| Reaction Details |
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 | Report a problem with these data |
| Target | Glutaminyl-peptide cyclotransferase |
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| Ligand | BDBM7939 |
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| Substrate/Competitor | BDBM7883 |
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| Meas. Tech. | QC Inhibition Testing |
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| pH | 8±n/a |
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| Temperature | 303.15±n/a K |
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| Ki | 192000±3000 nM |
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| Km | 48000±3000 nM |
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| kcat | 6±0.2 1/sec |
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| Citation |  Schilling, S; Cynis, H; von Bohlen, A; Hoffmann, T; Wermann, M; Heiser, U; Buchholz, M; Zunkel, K; Demuth, HU Isolation, catalytic properties, and competitive inhibitors of the zinc-dependent murine glutaminyl cyclase. Biochemistry44:13415-24 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Glutaminyl-peptide cyclotransferase |
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| Name: | Glutaminyl-peptide cyclotransferase |
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| Synonyms: | Glutaminyl Cyclase | Glutaminyl-tRNA cyclotransferase | QPCT_MOUSE | Qpct | mQC |
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| Type: | Enzyme |
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| Mol. Mass.: | 41122.35 |
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| Organism: | Mus musculus (mouse) |
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| Description: | n/a |
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| Residue: | 362 |
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| Sequence: | MAGSEDKRVVGTLHLLLLQATVLSLTAGNLSLVSAAWTQEKNHHQPAHLNSSSLQQVAEG
TSISEMWQNDLRPLLIERYPGSPGSYSARQHIMQRIQRLQAEWVVEVDTFLSRTPYGYRS
FSNIISTLNPEAKRHLVLACHYDSKYFPRWDSRVFVGATDSAVPCAMMLELARALDKKLH
SLKDVSGSKPDLSLRLIFFDGEEAFHHWSPQDSLYGSRHLAQKMASSPHPPGSRGTNQLD
GMDLLVLLDLIGAANPTFPNFFPKTTRWFNRLQAIEKELYELGLLKDHSLERKYFQNFGY
GNIIQDDHIPFLRKGVPVLHLIASPFPEVWHTMDDNEENLHASTIDNLNKIIQVFVLEYL
HL
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| BDBM7939 |
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| BDBM7883 |
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| Name | BDBM7939 |
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| Synonyms: | 1H-1,3-benzodiazole | Benzimidazole | Benzimidazole (Blm) | US9138393, Benzimidazole | US9144538, Benzimidazole |
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| Type | Small organic molecule |
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| Emp. Form. | C7H6N2 |
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| Mol. Mass. | 118.1359 |
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| SMILES | c1nc2ccccc2[nH]1 |
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| Structure | 
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