Ki Summary

Reaction Details

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Target

Non-receptor tyrosine-protein kinase TYK2 [580-1182]

Ligand

BDBM505115

Substrate/Competitor

n/a

Meas. Tech.

Enzymatic Inhibition Assay

IC50

4.70±n/a nM

Citation

Fernandes, P; Krawczuk, PJ; Tichenor, MS Small molecule inhibitors of the JAK family of kinases US Patent US11066406 Publication Date 7/20/2021

More Info.:

Get all data from this article, Assay Method

Non-receptor tyrosine-protein kinase TYK2 [580-1182]

Name:

Non-receptor tyrosine-protein kinase TYK2 [580-1182]

Synonyms:

TYK2 | TYK2 (aa 580-1182) | TYK2_HUMAN

Type:

n/a

Mol. Mass.:

68754.63

Organism:

Homo sapiens (Human)

Description:

P29597[580-1182]

Residue:

608

Sequence:

SFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRV
VLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWL
RRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSD
PGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRS
PSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLT
VNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQ
HRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQ
LLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVRE
DGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQM
TVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQ
APSVFSVC

BDBM505115

n/a

Name

BDBM505115

Synonyms:

US11066406, Ex. 9

Type

Small organic molecule

Emp. Form.

C22H24N8O

Mol. Mass.

416.479

SMILES

Cn1cc(NC(=O)Cc2nc3cnc4[nH]ccc4c3n2C2CCC(CC#N)CC2)cn1 |(14.72,2.54,;13.19,2.71,;12.16,1.56,;10.75,2.19,;9.42,1.42,;8.08,2.19,;8.08,3.73,;6.75,1.42,;5.42,2.19,;5.26,3.72,;3.75,4.04,;2.98,5.37,;1.44,5.37,;.67,4.04,;-.84,3.72,;-1,2.19,;.41,1.56,;1.44,2.71,;2.98,2.71,;4.01,1.56,;3.69,.06,;2.23,-.42,;1.91,-1.93,;3.05,-2.96,;2.73,-4.46,;3.87,-5.49,;5.02,-6.52,;4.51,-2.48,;4.83,-.98,;10.91,3.72,;12.42,4.04,)|

Structure