null
SMILES CN[C@@H]1CC2OC([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
InChI Key InChIKey=YISMQBFJYDFMAL-AESIHLKFSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 83 hits for monomerid = 139540
TargetSerine/threonine-protein kinase PLK2(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 813nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase WNK2(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 8.09E+3nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 0.190nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 0.180nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 3.67E+3nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 2.21nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 0.320nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 15.6nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 0.570nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1 [1-999,E255K](Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 438nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 385nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 62.2nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 143nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 37.3nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 184nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 7.40nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 4.01nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 3.64nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type II subunit gamma(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 0.700nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 243nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 8nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 4.66nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 1.70nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 0.550nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 39.5nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 24.3nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 150nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Nek1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 433nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetProtein kinase C zeta type(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 204nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 1.79E+3nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 720nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 87.5nMAssay Description:The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Gildead Sciences, Inc.
US Patent
Gildead Sciences, Inc.
US Patent
Affinity DataIC50: 6.30nMAssay Description:The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...More data for this Ligand-Target Pair
Affinity DataIC50: 4.97nMpH: 7.5 T: 2°CAssay Description:Briefly, specific kinase/substrate pairs along with required cofactors were prepared in reaction buffer. Compounds were delivered into the reaction, ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0192nMpH: 7.5 T: 2°CAssay Description:Briefly, specific kinase/substrate pairs along with required cofactors were prepared in reaction buffer. Compounds were delivered into the reaction, ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 0.196nMpH: 7.5 T: 2°CAssay Description:Briefly, specific kinase/substrate pairs along with required cofactors were prepared in reaction buffer. Compounds were delivered into the reaction, ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 0.365nMpH: 7.5 T: 2°CAssay Description:Briefly, specific kinase/substrate pairs along with required cofactors were prepared in reaction buffer. Compounds were delivered into the reaction, ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
G1 Therapeutics, Inc.
US Patent
G1 Therapeutics, Inc.
US Patent
Affinity DataIC50: 3.93nMAssay Description:Kinase enzymatic reactions were performed in 384-well microplates using a 12-channel Caliper LabChip instrument as a detection device. The enzymatic ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
G1 Therapeutics, Inc.
US Patent
G1 Therapeutics, Inc.
US Patent
TargetMitogen-activated protein kinase kinase kinase 5(Homo sapiens (Human))
Gildead Sciences, Inc.
US Patent
Gildead Sciences, Inc.
US Patent
Affinity DataIC50: 6.30nMAssay Description:The assay measures the phosphorylation level of a biotinylated peptide substrate by the ASK1 kinase using HTRF detection (6.1). This is a competitive...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
TAIHO PHARMACEUTICAL CO., LTD.
US Patent
TAIHO PHARMACEUTICAL CO., LTD.
US Patent
Affinity DataIC50: 63nMAssay Description:For setting the conditions for the method for measuring the in vitro inhibitory activity of a compound against HER2-phosphorylating activity, Profile...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
G1 Therapeutics, Inc.
US Patent
G1 Therapeutics, Inc.
US Patent
Affinity DataIC50: 4.06nMAssay Description:Potency determination of biochemical kinase inhibition test. Kinase activity test and IC50 determination. Firstly, 10 ng of recombinant CDK4/Cyclin D...More data for this Ligand-Target Pair
Affinity DataIC50: 10.8nMAssay Description:Potency determination of biochemical kinase inhibition test. Kinase activity test and IC50 determination. Firstly, 10 ng of recombinant CDK4/Cyclin D...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 0.508nMAssay Description:Table 3 and 4: The HotSpot kinase profiling and screening assays were carried out using the method of Anastassiadis et al., Nat. Biotechnol. (2011) V...More data for this Ligand-Target Pair
Affinity DataIC50: 174nMAssay Description:Table 7 For most assays, kinase-tagged T7 phage strains were prepared in an E. coli host derived from the BL21 strain. E. coli were grown to log-phas...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Temple University—Of The Commonwealth System Of Higher Education
US Patent
Affinity DataIC50: 0.508nMAssay Description:Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....More data for this Ligand-Target Pair
Affinity DataIC50: 0.508nMAssay Description:Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....More data for this Ligand-Target Pair
Affinity DataIC50: 0.508nMAssay Description:Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....More data for this Ligand-Target Pair
Affinity DataIC50: 22.6nMAssay Description:Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....More data for this Ligand-Target Pair
Affinity DataIC50: 0.808nMAssay Description:Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....More data for this Ligand-Target Pair