null
SMILES OCCN(CCc1c[nH]c2ccccc12)Cc1ccc(\C=C\C(=O)NO)cc1
InChI Key InChIKey=BWDQBBCUWLSASG-MDZDMXLPSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 51 hits for monomerid = 19428
TargetHistone deacetylase 1(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataKi: 0.600nMAssay Description:Inhibition of human HDAC1More data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataKi: 1.40nMAssay Description:Inhibition of human HDAC2More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataKi: 4.20nMAssay Description:Inhibition of human HDAC3More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataKi: 9.5nMAssay Description:Inhibition of human HDAC6More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataKi: 340nMAssay Description:Inhibition of human HDAC8More data for this Ligand-Target Pair
TargetHistone deacetylase 5(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataKi: 420nMAssay Description:Inhibition of human HDAC5More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataKi: 2.25E+3nMAssay Description:Inhibition of human HDAC4More data for this Ligand-Target Pair
TargetHistone deacetylase 9(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataKi: 9.00E+3nMAssay Description:Inhibition of human HDAC9More data for this Ligand-Target Pair
TargetHistone deacetylase 7(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataKi: 9.50E+3nMAssay Description:Inhibition of human HDAC7More data for this Ligand-Target Pair
TargetHistone deacetylase 5(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of human recombinant N-terminal FLAG-tagged HDAC5 (620-1122) expressed in baculovirus after 10 mins by fluorimetric analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 5(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human HDAC5 by fluorimetric assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 7(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 2.24E+3nMAssay Description:Inhibition of human recombinant N-terminal FLAG-tagged HDAC7 (438-915) expressed in baculovirus after 10 mins by fluorimetric analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of human recombinant N-terminal FLAG-tagged HDAC4 (612-1034) expressed in baculovirus after 10 mins by fluorimetric analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant C-terminal FLAG-tagged HDAC2 expressed in baculovirus after 10 mins by fluorimetric analysisMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant C-terminal FLAG-tagged HDAC1 expressed in baculovirus after 10 mins by fluorimetric analysisMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Institutes for Biomedical Research
Curated by ChEMBL
Novartis Institutes for Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.22E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by automated patch clamp electrophisiology assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of FLAG-tagged HDAC1 expressed in HEK293 cells by fluorescent assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human HDAC1 by fluorimetric assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 2(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of human HDAC2 by fluorimetric assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human HDAC3 by fluorimetric assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human HDAC8 by fluorimetric assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 5.80nMAssay Description:Inhibition of human HDAC4 by fluorimetric assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 7(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 6.10nMAssay Description:Inhibition of human HDAC7 by fluorimetric assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 9(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 8.20nMAssay Description:Inhibition of human HDAC9 by fluorimetric assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 5.90nMAssay Description:Inhibition of human HDAC6 by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.40nMAssay Description:Inhibition of human HDAC10 by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human HDAC11 by fluorimetric assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of purified recombinant HDAC1More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Institutes for Biomedical Research
Curated by ChEMBL
Novartis Institutes for Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of human ERG by automated patch clamp assayMore data for this Ligand-Target Pair
TargetCytochrome P450 3A4(Homo sapiens (Human))
Novartis Institutes for Biomedical Research
Curated by ChEMBL
Novartis Institutes for Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 0.400nMAssay Description:Inhibition of flag-tagged HDAC3More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of flag-tagged HDAC4More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of flag-tagged HDAC4 by pull-down assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of flag-tagged HDAC4 by Biomol assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of flag-tagged HDAC4 expressed in HEK293 cells by Biomol assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of HDAC4 catalytic domain expressed in HEK293 cells by Biomol assayMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Institutes for Biomedical Research
Curated by ChEMBL
Novartis Institutes for Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of human ERG by radioligand binding assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Institutes for Biomedical Research
Curated by ChEMBL
Novartis Institutes for Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Novartis Institutes for Biomedical Research
Curated by ChEMBL
Novartis Institutes for Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of human ERG by manual patch clamp assayMore data for this Ligand-Target Pair
TargetHistone deacetylase(Homo sapiens (Human))
Mazandaran University of Medical Sciences
Curated by ChEMBL
Mazandaran University of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibition of human H1299 cells derived HDAC using biotin-labeled SGRGKGGKGLGKGGAKRHRKVLRD peracetylated with [3H]acetate at lysine residue as substr...More data for this Ligand-Target Pair
TargetHistone deacetylase 6(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 8.30nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 420nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
Affinity DataIC50: 4.40nMpH: 7.5 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 3.60nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 2.60nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
TargetHistone deacetylase 8(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair
TargetHistone deacetylase(Homo sapiens (Human))
Mazandaran University of Medical Sciences
Curated by ChEMBL
Mazandaran University of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) enzyme obtained from H1299 human lung carcinoma cell lysatesMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
St Jude Children's Research Hospital
Curated by ChEMBL
St Jude Children's Research Hospital
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:For the enzyme assay, the enzyme fraction was added to fluorescent substrate in the presence of test compounds, and the mixture was incubated for add...More data for this Ligand-Target Pair