null

SMILES CCn1c(nc2cnccc12)-c1nonc1N

InChI Key InChIKey=UGHABJRZQKZAHP-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 14032   

TargetRho-associated protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)copy SMILEScopy InChI
Affinity DataIC50: 19nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F18WZBPubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human ROCK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DV1KBVPubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant N-terminal his-tagged ROCK1 (3-543) expressed in baculovirus infected Sf9 cells using Biotin-Ahx-AKRRLSSLRA-CONH2 sub...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DV1KBVPubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration exhibited towards MSK-1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z037P9PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibitory concentration against selected kinase DYRK1-alphaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75FVNPubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibitory concentration against selected kinase ROCK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75FVNPubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)copy SMILEScopy InChI
Affinity DataIC50: 110nMMore data for this Ligand-Target Pair
In DepthDetails
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Inhibitory concentration against selected kinase p70S6KMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75FVNPubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration against MSK-1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75FVNPubMed
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)copy SMILEScopy InChI
In DepthDetails
TargetRibosomal protein S6 kinase alpha-1(Homo sapiens (Human))TBA
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)copy SMILEScopy InChI
Affinity DataIC50: 24nMMore data for this Ligand-Target Pair
In DepthDetails
TargetRho-associated protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)copy SMILEScopy InChI
Affinity DataIC50: 13nMMore data for this Ligand-Target Pair
In DepthDetails
TargetCyclin-dependent kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)copy SMILEScopy InChI
Affinity DataIC50: 169nMMore data for this Ligand-Target Pair
In DepthDetails
TargetCyclin-dependent kinase 2(Homo sapiens (Human))TBA
LigandPNGBDBM14032(4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...)copy SMILEScopy InChI
Affinity DataIC50: 169nMAssay Description:Inhibitory concentration against selected kinase CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2S75FVNPubMed