null
SMILES CCn1c(nc2cnccc12)-c1nonc1N
InChI Key InChIKey=UGHABJRZQKZAHP-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 14032
Affinity DataIC50: 19nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
TargetRho-associated protein kinase 2(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals Inc.
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human ROCK2More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant N-terminal his-tagged ROCK1 (3-543) expressed in baculovirus infected Sf9 cells using Biotin-Ahx-AKRRLSSLRA-CONH2 sub...More data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration exhibited towards MSK-1More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibitory concentration against selected kinase DYRK1-alphaMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibitory concentration against selected kinase ROCK1More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
In DepthDetails
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibitory concentration against selected kinase p70S6KMore data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration against MSK-1More data for this Ligand-Target Pair
TargetRibosomal protein S6 kinase alpha-5(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
GlaxoSmithKline Pharmaceuticals
Curated by ChEMBL
In DepthDetails
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Affinity DataIC50: 169nMAssay Description:Inhibitory concentration against selected kinase CDK2More data for this Ligand-Target Pair