null

SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1cnccn1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 172166   

TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172166(EPZ008280 | US10155002, Compound 174 | US11052093,...)copy SMILES
Affinity DataIC50: 6.70nMT: 2°CAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2057DPXUS Patent
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172166(EPZ008280 | US10155002, Compound 174 | US11052093,...)copy SMILES
Affinity DataIC50: 2.89nMT: 2°CAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2057DPXUS Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172166(EPZ008280 | US10155002, Compound 174 | US11052093,...)copy SMILES
Affinity DataIC50: 6.70nMAssay Description:Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZW1JQPUS Patent
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172166(EPZ008280 | US10155002, Compound 174 | US11052093,...)copy SMILES
Affinity DataIC50: 2.90nMAssay Description:Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZW1JQPUS Patent
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172166(EPZ008280 | US10155002, Compound 174 | US11052093,...)copy SMILES
Affinity DataIC50: 2.89nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SB48WPUS Patent
TargetHistone-lysine N-methyltransferase EZH2 [A687V](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172166(EPZ008280 | US10155002, Compound 174 | US11052093,...)copy SMILES
Affinity DataIC50: 3.90nMAssay Description:Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZW1JQPUS Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172166(EPZ008280 | US10155002, Compound 174 | US11052093,...)copy SMILES
Affinity DataIC50: 6.70nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KS6TM3US Patent
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172166(EPZ008280 | US10155002, Compound 174 | US11052093,...)copy SMILES
Affinity DataIC50: 2.89nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KS6TM3US Patent
TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172166(EPZ008280 | US10155002, Compound 174 | US11052093,...)copy SMILES
Affinity DataIC50: 6.70nMAssay Description:The assays were all performed in a buffer consisting of 20 mM bicine (pH=7.6), 0.5 mM DTT, 0.005% BSG and 0.002% Tween20, prepared on the day of use....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SB48WPUS Patent
TargetHistone-lysine N-methyltransferase EZH2 [A677G](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM172166(EPZ008280 | US10155002, Compound 174 | US11052093,...)copy SMILES
Affinity DataIC50: 2.80nMAssay Description:Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZW1JQPUS Patent