null

SMILES CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(Br)c(C)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 190209   

TargetHistone-lysine N-methyltransferase EZH2(Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM190209(EPZ008686 | US9175331, 45)copy SMILES
Affinity DataIC50: 7.30nMAssay Description:Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZW1JQPUS Patent
TargetHistone-lysine N-methyltransferase EZH2 [A687V](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM190209(EPZ008686 | US9175331, 45)copy SMILES
Affinity DataIC50: 9.60nMAssay Description:Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZW1JQPUS Patent
TargetHistone-lysine N-methyltransferase EZH2 [A677G](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM190209(EPZ008686 | US9175331, 45)copy SMILES
Affinity DataIC50: 4.5nMAssay Description:Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZW1JQPUS Patent
TargetHistone-lysine N-methyltransferase EZH2 [Y641F](Homo sapiens (Human))
Epizyme, Inc.

US Patent
LigandPNGBDBM190209(EPZ008686 | US9175331, 45)copy SMILES
Affinity DataIC50: 5.5nMAssay Description:Test compounds were serially diluted 3-fold in DMSO in a 10 point-curve and 1 uL was spotted into a 384-well microplate in duplicate using a Platemat...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZW1JQPUS Patent