null

SMILES CN1[C@H]2CC[C@@H]1[C@H]([C@H](C2)c1ccc(Cl)cc1)c1ncc(s1)-c1ccc(cc1)[N+]([O-])=O

InChI Key InChIKey=YTNASRCFNXLDGR-HIUFNZKISA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 22403   

TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Research Triangle Institute

LigandPNGBDBM22403(2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-aza...)copy SMILEScopy InChI
Affinity DataKi:  6.10nM EC50:  30nMAssay Description:Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Research Triangle Institute

LigandPNGBDBM22403(2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-aza...)copy SMILEScopy InChI
Affinity DataKi:  980nM ΔG°:  -8.19kcal/molepH: 7.4 T: 2°CAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Research Triangle Institute

LigandPNGBDBM22403(2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-aza...)copy SMILEScopy InChI
Affinity DataKi:  1.82E+3nM EC50:  3.60E+3nMAssay Description:Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
TargetTransporter(Rattus norvegicus (rat))
Research Triangle Institute

LigandPNGBDBM22403(2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-aza...)copy SMILEScopy InChI
Affinity DataKi: >2.00E+3nMAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Research Triangle Institute

LigandPNGBDBM22403(2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-aza...)copy SMILEScopy InChI
Affinity DataKi:  2.27E+3nM EC50:  582nMAssay Description:Membranes were preincubated with drugs before the addition of [125I]RTI-55. The reaction was terminated by filtration through Wallac Filtermat A filt...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Research Triangle Institute

LigandPNGBDBM22403(2-[(1R,2S,3S,5S)-3-(4-chlorophenyl)-8-methyl-8-aza...)copy SMILEScopy InChI
Affinity DataIC50: 20nMpH: 7.4 T: 2°CAssay Description:Brains from male Sprague-Dawley rats were removed, dissected, and rapidly frozen. Ligand binding experiments were conducted in assay tubes containing...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8Q4TPubMed