null

SMILES COc1ccc(CN(CCN(C)C)c2ccccn2)cc1

InChI Key InChIKey=YECBIJXISLIIDS-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 43 hits for monomerid = 22567   

TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
University of North Carolina at Chapel Hill

Curated by PDSP Ki Database
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataKi:  0.570nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ0ZK1PubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataKi:  0.710nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27M0B6TPubMedDrugBank
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
University of North Carolina at Chapel Hill

Curated by PDSP Ki Database
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataKi:  0.740nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ0ZK1PubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataKi:  0.950nMAssay Description:Binding affinity to human histamine H1 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3NKCPubMedDrugBank
TargetHistamine H1 receptor(Homo sapiens (Human))
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataKi:  1.01nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ0ZK1PubMedDrugBank
TargetHistamine H1 receptor(Homo sapiens (Human))
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataKi:  1.18nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ0ZK1PubMedDrugBank
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
University of North Carolina at Chapel Hill

Curated by PDSP Ki Database
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataKi:  1.25nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70DB4PubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]mepyramine from human wild type N-terminal hemagglutinin-tagged histamine H1 receptor expressed in HEK293T cells after 4 hrs by m...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44S8ZPubMedDrugBank
TargetHistamine H1 receptor(Homo sapiens (Human))
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P55PWCPubMedDrugBank
TargetHistamine H1 receptor(Homo sapiens (Human))
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor expressed in HEK-293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q241XVPubMedDrugBank
TargetHistamine H1 receptor(Homo sapiens (Human))
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29ZHXPubMedDrugBank
TargetHistamine H1 receptor(Homo sapiens (Human))
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataKi:  2.09nMAssay Description:Displacement of [3H]mepyramine from human histamine H1 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8T85PubMedDrugBank
TargetHistamine H1 receptor(Homo sapiens (Human))
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataKi:  2.5nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057DHPPubMedDrugBank
TargetHistamine H1 receptor(Homo sapiens (Human))
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataKi:  3.70nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ57BRPubMedDrugBank
TargetHistamine H1 receptor(Homo sapiens (Human))
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataKi:  3.98nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H70DB4PubMedDrugBank
TargetHistamine H1 receptor(Homo sapiens (Human))
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21N7ZMSPubMedDrugBank
TargetHistamine H1 receptor(Homo sapiens (Human))
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataKi:  4.47nMAssay Description:Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28K7BB7PubMedDrugBank
TargetHistamine H1 receptor(RAT)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataKi:  4.5nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN14P6PubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataKi:  4.70nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ3XFNPubMedDrugBank
TargetHrh3 protein(RAT)
Glaxo Research & Development Ltd.

Curated by PDSP Ki Database
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataKi:  7.94E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZG6QSDPubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
R.W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DR2T2HPubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BZ64JGPubMed
TargetHrh3 protein(RAT)
Glaxo Research & Development Ltd.

Curated by PDSP Ki Database
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZG6QSDPubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Vrije Universiteit Amsterdam

LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nM ΔG°: >-7.09kcal/molepH: 7.4 T: 2°CAssay Description:Ligand displacement assays were performed on The SK-N-MC/hH4R cell homogenates. Retained radioactivity was determined by liquid scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD1W6VPubMed
TargetHrh3 protein(RAT)
Glaxo Research & Development Ltd.

Curated by PDSP Ki Database
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63KF2PubMed
TargetHistamine H1 receptor(RAT)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataIC50: 5.75nMAssay Description:Displacement of [3H]mepyramine from histamine H1 receptor in Sprague-Dawley rat brain membrane after 2 hr by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN17BZPubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataIC50: 46.8nMAssay Description:Antagonist activity at H1 receptor in human HeLa cells assessed as inhibition of histamine-induced Ca2+ release by using fura-2AM-based fluorescence ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN17BZPubMedDrugBank
TargetHistamine H1 receptor(Homo sapiens (Human))
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataIC50: 0.820nMAssay Description:Binding affinity to human histamine H1 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87C5QPubMedDrugBank
TargetHistamine H1 receptor(Homo sapiens (Human))
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibitory activity against human Histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5PF7PubMedDrugBank
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibitory concentration against IKr potassium channelMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q208661KPubMed
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
University of North Carolina at Chapel Hill

Curated by PDSP Ki Database
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataKd:  0.851nMAssay Description:Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28K7BB7PubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataIC50: 0.0140nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67JS7PubMedDrugBank
TargetHistamine H1 receptor(Homo sapiens (Human))
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:Displacement of [3H]Pyrilamine from human recombinant histamine H1 receptor expressed in CHOK1 cells after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P55PWCPubMedDrugBank
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
University of North Carolina at Chapel Hill

Curated by PDSP Ki Database
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:In vitro antagonistic activity at the Histamine H1 receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2T152VBPubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Binding affinity to human histamine H1 receptor by radioligand displacement assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3NKCPubMedDrugBank
TargetHistamine H1 receptor(Homo sapiens (Human))
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Antagonist activity at human recombinant H1 receptor assessed as inhibition of histamine-induced intracellular Ca2+ releaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29ZHXPubMedDrugBank
TargetHistamine H1 receptor(Homo sapiens (Human))
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataEC50:  2.60nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V98907PubMedDrugBank
TargetHistamine H1 receptor(Homo sapiens (Human))
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inverse agonist activity at human wild-type histamine H1 receptor assessed as NF-kappaB activation after 48 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ415PPubMedDrugBank
TargetHistamine H1 receptor(Cavia porcellus (domestic guinea pig))
University of North Carolina at Chapel Hill

Curated by PDSP Ki Database
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Inhibition of guinea pig histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6S69PubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Displacement of [3H]pyrilamine from human recombinant H1 receptor expressed in HEK293 cells measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9S3SPubMedDrugBank
TargetHistamine H1 receptor(Homo sapiens (Human))
The University of Newcastle

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Displacement of [3H]pyrilamine from human recombinant histamine H1 receptor in HEK293 cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27M0B6TPubMedDrugBank
TargetBile salt export pump(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP488MPubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
Universit£ degli Studi di Urbino Carlo Bo

Curated by ChEMBL
LigandPNGBDBM22567(3H]pyrilamine | CHEMBL511 | Dorantamin | Mepyramin...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Inhibitory concentration against human Adenosine A3 receptor expressed in HEK293 cells using 0.1 nM [3H]AB-MECAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28C9X1XPubMed