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SMILES O=C(C(=O)c1ccc(cc1)C(=O)C(=O)c1ccccc1)c1ccccc1

InChI Key InChIKey=FUEGWHHUYNHBNI-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 22759   

TargetCoagulation factor XII(Homo sapiens (Human))
University of Mississippi

LigandPNGBDBM22759(1-[4-(2-oxo-2-phenylacetyl)phenyl]-2-phenylethane-...)copy SMILEScopy InChI
Affinity DataKi:  5.60nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44DRPubMed
TargetCoagulation factor XII(Homo sapiens (Human))
University of Mississippi

LigandPNGBDBM22759(1-[4-(2-oxo-2-phenylacetyl)phenyl]-2-phenylethane-...)copy SMILEScopy InChI
Affinity DataKi:  5.60nM ΔG°:  -11.2kcal/molepH: 7.4 T: 2°CAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q52MWQPubMed
TargetLiver carboxylesterase 1(Oryctolagus cuniculus (rabbit))
University of Mississippi

LigandPNGBDBM22759(1-[4-(2-oxo-2-phenylacetyl)phenyl]-2-phenylethane-...)copy SMILEScopy InChI
Affinity DataKi:  6.10nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44DRPubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM22759(1-[4-(2-oxo-2-phenylacetyl)phenyl]-2-phenylethane-...)copy SMILEScopy InChI
Affinity DataKi:  7.94nMAssay Description:Inhibition of human carboxylesterase 1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3NFKPubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM22759(1-[4-(2-oxo-2-phenylacetyl)phenyl]-2-phenylethane-...)copy SMILEScopy InChI
Affinity DataKi:  8nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44DRPubMed
TargetLiver carboxylesterase 1(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM22759(1-[4-(2-oxo-2-phenylacetyl)phenyl]-2-phenylethane-...)copy SMILEScopy InChI
Affinity DataKi:  8nMAssay Description:CE inhibition was determined using a spectrophotometric multiwell plate assay with o-NPA as a substrate. The rate of change in absorbance at 420 nm w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q52MWQPubMed
TargetCholinesterase(Homo sapiens (Human))
St. Jude Research Hospital

LigandPNGBDBM22759(1-[4-(2-oxo-2-phenylacetyl)phenyl]-2-phenylethane-...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q52MWQPubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
St. Jude Research Hospital

LigandPNGBDBM22759(1-[4-(2-oxo-2-phenylacetyl)phenyl]-2-phenylethane-...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q52MWQPubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
St. Jude Research Hospital

LigandPNGBDBM22759(1-[4-(2-oxo-2-phenylacetyl)phenyl]-2-phenylethane-...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44DRPubMed
TargetCholinesterase(Homo sapiens (Human))
St. Jude Research Hospital

LigandPNGBDBM22759(1-[4-(2-oxo-2-phenylacetyl)phenyl]-2-phenylethane-...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+5nMAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Estimates of the competitive inhibition constants (Ki) were ob...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44DRPubMed