null

SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(OC)cc4F)c3c2s1

InChI Key InChIKey=RYBNARZBIXTFJS-UHFFFAOYSA-N

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 45 hits for monomerid = 246383   

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
DIAXONHIT

US Patent
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 0.360nMpH: 7.5 T: 2°CAssay Description:The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2610Z7JUS Patent
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))TBA
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CLK1 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))TBA
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CLK2 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD22MPPubMed
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))TBA
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CLK3 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD22MPPubMed
TargetDual specificity protein kinase CLK4(Homo sapiens (Human))TBA
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CLK4 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
DIAXONHIT

US Patent
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of DYRK1A (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD22MPPubMed
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of DYRK1B (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD22MPPubMed
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of DYRK2 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of MLK1 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD22MPPubMed
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of MLK2 (unknown origin) by NanoBRET cellular target engagement assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD22MPPubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
DIAXONHIT

US Patent
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 0.360nMAssay Description:Inhibition of human DYRK1A using [33P]-ATP incubated for 120 minsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9NMGPubMed
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 0.590nMAssay Description:Inhibition of human DYRK1B using [33P]-ATP incubated for 120 minsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9NMGPubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
DIAXONHIT

US Patent
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 0.360nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9NMGPubMed
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 0.590nMAssay Description:Inhibition of DYRK1B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9NMGPubMed
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:Inhibition of DYRK2 (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of DYRK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9NMGPubMed
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 1.57E+3nMAssay Description:Inhibition of DYRK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9NMGPubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))TBA
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of CLK1 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))TBA
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:Inhibition of CLK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9NMGPubMed
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))TBA
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of CLK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9NMGPubMed
TargetDual specificity protein kinase CLK4(Homo sapiens (Human))TBA
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Inhibition of CLK4 (unknown origin)More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))TBA
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 9.10nMAssay Description:Inhibition of GSK3A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9NMGPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 143nMAssay Description:Inhibition of GSK3B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9NMGPubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
DIAXONHIT

US Patent
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataKd:  7.30nMAssay Description:Binding affinity to DYRK1A (unknown origin) assessed as dissociation constant at 3 uM by ITC assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9NMGPubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
DIAXONHIT

US Patent
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 0.360nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90DP7PubMed
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 0.590nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90DP7PubMed
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))TBA
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))TBA
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 1.21E+3nMMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))TBA
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))TBA
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails
TargetDual specificity protein kinase CLK4(Homo sapiens (Human))TBA
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 80nMMore data for this Ligand-Target Pair
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 81nMMore data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 5.33E+3nMMore data for this Ligand-Target Pair
In DepthDetails
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))TBA
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 111nMMore data for this Ligand-Target Pair
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 25nMMore data for this Ligand-Target Pair
In DepthDetails
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
DIAXONHIT

US Patent
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataKd:  5.20nMMore data for this Ligand-Target Pair
In DepthDetails
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))TBA
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataKd:  7.60nMMore data for this Ligand-Target Pair
LigandPNGBDBM246383(US9446044, 69)copy SMILEScopy InChI
Affinity DataIC50: 0.590nMpH: 7.5 T: 2°CAssay Description:The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2610Z7JUS Patent