null
SMILES [O-]N=O
InChI Key InChIKey=IOVCWXUNBOPUCH-UHFFFAOYSA-M
PDB links: 156 PDB IDs match this monomer. 530 PDB IDs contain this monomer as substructures. 530 PDB IDs contain inhibitors having a similarity of 90% to this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 59 hits for monomerid = 26989
Affinity DataKi: 6.12E+4nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
Affinity DataKi: 6.70E+5nM ΔG°: -4.33kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity Khalifah RG. The carbon dioxide hy...More data for this Ligand-Target Pair
Affinity DataKi: 7.70E+5nMAssay Description:Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assayChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 8.20E+5nMAssay Description:Inhibition of human recombinant CA6 by stopped-flow CO2 hydration assayChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 9.30E+5nM ΔG°: -4.06kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition of Vibrio cholerae alpha carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 9.30E+5nM ΔG°: -4.13kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity Khalifah RG. The carbon dioxide hy...More data for this Ligand-Target Pair
TargetCarbonic anhydrase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
University of Florida
Curated by ChEMBL
University of Florida
Curated by ChEMBL
Affinity DataKi: 9.40E+5nMpH: 8.3Assay Description:Inhibition of Pseudomonas aeruginosa PAO1 type-2 beta-carbonic anhydrase psCA3 expressed in Escherichia coli Tuner BL21 (DE3) cells pre-incubated for...More data for this Ligand-Target Pair
Affinity DataKi: 1.78E+6nMAssay Description:Inhibition of human recombinant CA7More data for this Ligand-Target Pair
Affinity DataKi: 3.15E+6nMAssay Description:Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assayChecked by AuthorMore data for this Ligand-Target Pair
TargetCarbonic anhydrase(Methanosarcina thermophila)
Istituto di Biochimica delle Proteine - CNR
Curated by ChEMBL
Istituto di Biochimica delle Proteine - CNR
Curated by ChEMBL
Affinity DataKi: 6.80E+6nMAssay Description:Inhibition of Methanosarcina thermophila recombinant gamma-CA by CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase(Methanosarcina thermophila)
Istituto di Biochimica delle Proteine - CNR
Curated by ChEMBL
Istituto di Biochimica delle Proteine - CNR
Curated by ChEMBL
Affinity DataKi: 6.80E+6nMAssay Description:Inhibition of Methanosarcina thermophila recombinant carbonic anhydrase gamma assessed as inhibition of CO2 hydration preincubated for 15 mins by Lin...More data for this Ligand-Target Pair
TargetCarbonic anhydrase(Methanosarcina thermophila)
Istituto di Biochimica delle Proteine - CNR
Curated by ChEMBL
Istituto di Biochimica delle Proteine - CNR
Curated by ChEMBL
Affinity DataKi: 6.80E+6nMAssay Description:Inhibitory constant against Zn-Cam (Methanosarcina thermophila)More data for this Ligand-Target Pair
TargetCarbonic anhydrase(Methanosarcina thermophila)
Istituto di Biochimica delle Proteine - CNR
Curated by ChEMBL
Istituto di Biochimica delle Proteine - CNR
Curated by ChEMBL
Affinity DataKi: 6.80E+6nMAssay Description:Inhibition of archaeon Methanosarcina thermophila gamma-CA after 15 mins by stopped-flow/Co2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 8.40E+6nMAssay Description:Inhibitory activity against human carbonic anhydrase I expressed in Escherichia coliChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 8.40E+6nM ΔG°: -2.78kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
Affinity DataKi: 8.40E+6nMAssay Description:Inhibition constant of anion against human carbonic anhydrase isozyme hCA IMore data for this Ligand-Target Pair
Affinity DataKi: 8.40E+6nMAssay Description:Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assayChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 8.40E+6nMAssay Description:Inhibition of human carbonic anhydrase-1 at 20 degC preincubated for 15 mins by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 8.40E+6nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 8.40E+6nMAssay Description:Inhibition of human recombinant wild type CA1 by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 8.40E+6nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 8.40E+6nMAssay Description:Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 8.40E+6nMAssay Description:Inhibition of human carbonic anhydrase 1 by Lineweaver-Burk curvesMore data for this Ligand-Target Pair
Affinity DataKi: 8.40E+6nMAssay Description:Inhibitory constant against carbonic anhydrase IMore data for this Ligand-Target Pair
Affinity DataKi: 8.40E+6nMpH: 8.3Assay Description:Inhibition of recombinant human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay at pH 8.3More data for this Ligand-Target Pair
Affinity DataKi: 8.40E+6nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase 1 after 15 mins by CO2 hydrase assay at pH 7.5More data for this Ligand-Target Pair
Affinity DataKi: 8.40E+6nM ΔG°: -2.78kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 8.70E+6nM ΔG°: -2.76kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition of Vibrio cholerae recombinant carbonic anhydrase gamma expressed in Escherichia coli DE3 cells preincubated for 15 mins by stopped-flow C...More data for this Ligand-Target Pair
Affinity DataKi: 9.10E+6nM ΔG°: -2.74kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition of Vibrio cholerae carbonic anhydrase beta preincubated for 15 mins by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.26E+7nMAssay Description:Inhibitory activity against mouse carbonic anhydrase XIII expressed in Escherichia coli TOP 10Checked by AuthorMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 5A, mitochondrial(Homo sapiens (Human))
Ondokuz Mayis University
Curated by ChEMBL
Ondokuz Mayis University
Curated by ChEMBL
Affinity DataKi: 1.60E+7nMAssay Description:Inhibition of human carbonic anhydrase 5 by Lineweaver-Burk curvesMore data for this Ligand-Target Pair
Affinity DataKi: 3.08E+7nMAssay Description:Inhibition of human carbonic anhydrase 4 by Lineweaver-Burk curvesMore data for this Ligand-Target Pair
Affinity DataKi: 3.08E+7nMAssay Description:Inhibition constant of anion against human carbonic anhydrase isozyme hCA IVMore data for this Ligand-Target Pair
Affinity DataKi: 3.08E+7nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
TargetCarbonic anhydrase(Vibrio cholerae serotype O1 (strain ATCC 39315 / E...)
Universit£ degli Studi di Firenze
Universit£ degli Studi di Firenze
Affinity DataKi: 3.41E+7nM ΔG°: -1.97kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition of Flaveria bidentis carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase(Methanobacterium thermoautotrophicum)
Universit£ degli Studi di Firenze
Curated by ChEMBL
Universit£ degli Studi di Firenze
Curated by ChEMBL
Affinity DataKi: 4.48E+7nMAssay Description:Inhibitory constant against methanoarchaeon Methanobacterium thermoautotrophicum (Cab)More data for this Ligand-Target Pair
Affinity DataKi: 6.30E+7nMAssay Description:Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 6.30E+7nMAssay Description:Inhibition of human CA2 incubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 6.30E+7nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 assessed as inhibition of CO2 hydration incubated for 15 mins prior to testing by stopped flow C...More data for this Ligand-Target Pair
Affinity DataKi: 6.30E+7nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 assessed as inhibition of CO2 hydration preincubated for 15 mins by Lineweaver-burk plot methodMore data for this Ligand-Target Pair
Affinity DataKi: 6.30E+7nMAssay Description:Inhibition of human carbonic anhydrase 2 by Lineweaver-Burk curvesMore data for this Ligand-Target Pair
Affinity DataKi: 6.30E+7nMAssay Description:Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 6.30E+7nMAssay Description:Inhibition of human recombinant wild type CA2 by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 6.30E+7nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 6.30E+7nMAssay Description:Inhibition of human cytosolic carbonic anhydrase-2 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 6.30E+7nMAssay Description:Inhibition constant of anion against human carbonic anhydrase isozyme hCA IIMore data for this Ligand-Target Pair
Affinity DataKi: 6.30E+7nMAssay Description:Inhibitory activity against human carbonic anhydrase II expressed in Escherichia coliChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 6.30E+7nMAssay Description:Inhibitory constant against carbonic anhydrase IIMore data for this Ligand-Target Pair
Affinity DataKi: 6.30E+7nMpH: 8.3Assay Description:Inhibition of recombinant human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay at pH 8.3More data for this Ligand-Target Pair
Affinity DataKi: 6.30E+7nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5More data for this Ligand-Target Pair