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SMILES Nc1ncnc2c3cc(cnc3sc12)-c1ccccc1

InChI Key InChIKey=KOEWWBBSRQMABA-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 27437   

LigandPNGBDBM27437(12-phenyl-8-thia-3,5,10-triazatricyclo[7.4.0.0^{2,...)copy SMILEScopy InChI
Affinity DataKi:  900nM ΔG°:  -8.57kcal/mole IC50: 9.00E+3nMpH: 7.5 T: 2°CAssay Description:The assay was carried out in the reaction buffer containing Cdc7/Dbf4, His6-MCM2, and ATP/[gamma-33P]ATP in the presence of test compounds. After inc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3HG2PubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
UMR 6014& FR 3038; Univ Rouen; INSA Rouen; CNRS

Curated by ChEMBL
LigandPNGBDBM27437(12-phenyl-8-thia-3,5,10-triazatricyclo[7.4.0.0^{2,...)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:Inhibition of human recombinant GST-tagged CLK1 expressed in Escherichia coli using GRSRSRSRSRSR as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BR8TVGPubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(RAT)
UMR 6014& FR 3038; Univ Rouen; INSA Rouen; CNRS

Curated by ChEMBL
LigandPNGBDBM27437(12-phenyl-8-thia-3,5,10-triazatricyclo[7.4.0.0^{2,...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of rat recombinant GST-tagged DYRK1A expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate after 30 mins by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BR8TVGPubMed