null
SMILES COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OC
InChI Key InChIKey=LSPANGZZENHZNJ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 65 hits for monomerid = 3032
Affinity DataKi: 0.00600nMAssay Description:Inhibition of EGFRChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase transforming protein Abl(Abelson murine leukemia virus)
Novartis Pharmaceuticals
Novartis Pharmaceuticals
Affinity DataIC50: 30nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+3nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Novartis Pharmaceuticals
Novartis Pharmaceuticals
Affinity DataIC50: 1.00E+5nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMpH: 7.6 T: 2°CAssay Description:The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.More data for this Ligand-Target Pair
Affinity DataIC50: 200nMpH: 7.4 T: 2°CAssay Description:Cells used were tumor cell lines naturally expressing high levels of tyrosine kinases. Expression levels at the RNA level were derived from the NCI D...More data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:In vitro inhibitory activity against epidermal growth factor receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of Cyclin-dependent kinase 2More data for this Ligand-Target Pair
Affinity DataKd: 8.10E+3nMAssay Description:Equilibrium binding constant for EPH receptor B2More data for this Ligand-Target Pair
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of EPH receptor B2 using ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of EGFR tyrosine kinase activityMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0250nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.0290nMAssay Description:Inhibition of epidermal growth factor receptor kinase (unknown origin) using [33P]-ATP after 20 to 30 mins by radiometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of EGFR (unknown origin) expressed in human tumor cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of epidermal growth factor receptor (EGF-R) autophosphorylation in A431 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.19E+4nMAssay Description:Inhibition of PDGF-BB induced PDGF-B receptor autophosphorylation in rat mesangial cells.More data for this Ligand-Target Pair
Affinity DataIC50: 0.0250nMAssay Description:Competitive binding affinity to EGFR (unknown origin) ATP binding siteMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of EGFR phosphorylation in human A431 cells after 10 mins by FLISAMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
Spanish National Cancer Research Centre (CNIO)
Curated by ChEMBL
Affinity DataIC50: 63nMAssay Description:Inhibition of human EGFR-mediated poly(Glu4Tyr) phosphorylation after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of EGFR tyrosine kinase activity in EGF-stimulated human A431 cells after 60 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Compound was evaluated for its concentration required to inhibit the porcine kidney F16BPaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Compound was evaluated for its concentration required to inhibit the rat liver F16BPaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of EGF-induced EGFR autophosphorylation in human A431 cells incubated for 60 mins prior to EGF-induction measured after 10 mins by phospho...More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of autophosphorylation of cytoplasmic domain of epidermal growth factor receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0250nMAssay Description:Concentration required to inhibit the phosphorylation of a 14-residue fragment of phospholipase C gamma 1 by Epidermal growth factor receptor from A4...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0290nMAssay Description:Inhibitory potency against isolated epidermal growth factor receptor (EGFR) from human A431 carcinoma cellsMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human VEGFR2 in presence of 1 mM ATPMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Wyeth Research
Curated by ChEMBL
Wyeth Research
Curated by ChEMBL
Affinity DataIC50: 1.49E+3nMAssay Description:Inhibition of human VEGFR2 in presence of 1 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human EGFR in presence of 1 uM ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human EGFR in presence of 1 mM ATPMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Lawrence Berkeley National Laboratory
Curated by ChEMBL
Lawrence Berkeley National Laboratory
Curated by ChEMBL
Affinity DataIC50: 49nMAssay Description:Inhibition of human ErbB4 tyrosine kinase phosphorylation expressed in human CEM/4 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.660nMAssay Description:Displacement of [125I]4-(3-iodoanilino)-6,7-dimethoxyquinazoline from EGFR tyrosine kinase in human A431 cell membranesMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Lawrence Berkeley National Laboratory
Curated by ChEMBL
Lawrence Berkeley National Laboratory
Curated by ChEMBL
Affinity DataIC50: 143nMAssay Description:Inhibition of human ErbB2 tyrosine kinase phosphorylation expressed in mouse BaF3 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human EGFR tyrosine kinase phosphorylation expressed in mouse BaF3 cellsMore data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University of Bonn
Curated by ChEMBL
University of Bonn
Curated by ChEMBL
Affinity DataIC50: 2.32E+3nMAssay Description:Inhibition of human BCRP expressed in MDCK2 cells assessed as pheophorbide A accumulation treated 30 mins before pheophorbide A addition measured up ...More data for this Ligand-Target Pair
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University of Bonn
Curated by ChEMBL
University of Bonn
Curated by ChEMBL
Affinity DataIC50: 1.73E+3nMAssay Description:Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation treated 30 mins before Hoechst 33342 addition measured up to...More data for this Ligand-Target Pair
Affinity DataIC50: 70.8nMAssay Description:Inhibition autophosphorylation of EGFR in human DiFi cells after 2 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of EGFR in human A431 cells assessed as inhibition of EGF-induced tyrosine phosphorylation incubated for 60 mins prior to EGF-activation m...More data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of EGF-induced EGFR phosphorylation in human A431 cells overexpressing EGFR pretreated for 60 mins prior to EGF addition measured after 10...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0250nMAssay Description:Inhibition of EGFRChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of EGFR in human A431 cells by phosphotyrosine cell-based ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of human EGFR kinase activityMore data for this Ligand-Target Pair
Affinity DataIC50: 230nMAssay Description:Inhibition of EGFR expressed in human A431 cellsMore data for this Ligand-Target Pair