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SMILES Cc1csc2c(nc(Cl)nc12)-n1nc(Nc2ccc(OCCN3CCCC3)cc2)nc1N

InChI Key InChIKey=GTXOGZFFTJTKAX-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 313081   

TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM313081(1-(2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)-N...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:The resulting chemiluminescence was read with a Luminomitor within 10 minutes to minimize changes in signal intensity. After reading the chemilumines...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21N836FUS Patent
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM313081(1-(2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)-N...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of N-terminal GST-tagged human Axl (464 to 885 end residues) cytoplasmic domain expressed in baculovirus expression system using HS1 pepti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26D5WH0PubMed
TargetInsulin receptor(Homo sapiens (Human))
Rigel Pharmaceuticals, 1180 Veterans Blvd., South San Francisco, CA 94080, USA. Electronic address: dagoff@att.net.

Curated by ChEMBL
LigandPNGBDBM313081(1-(2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)-N...)copy SMILEScopy InChI
Affinity DataEC50:  582nMAssay Description:Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26D5WH0PubMed
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Rigel Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM313081(1-(2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)-N...)copy SMILEScopy InChI
Affinity DataEC50:  12nMAssay Description:Inhibition of Axl in human HeLa cells assessed as reduction in AKT phosphorylation at Ser 473 residues pre-incubated for 1 hr before preclustered ant...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26D5WH0PubMed