null

SMILES Fc1ccc(cn1)-c1ccc2nc(sc2c1)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)CCC(F)(F)F

InChI Key InChIKey=DTLRWTWWBBABSY-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 319014   

TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb Company

US Patent
LigandPNGBDBM319014(N-[(cyclopropyl- carbamoyl) methyl]-2-[6-(6- fluor...)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Endothelial lipase (EL) and hepatic lipase (HL) activities were measured using a fluorescent substrate, A10070, (Invitrogen, CA) doped into an artifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2N018M8US Patent
TargetEndothelial lipase(Mus musculus (Mouse))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM319014(N-[(cyclopropyl- carbamoyl) methyl]-2-[6-(6- fluor...)copy SMILEScopy InChI
Affinity DataIC50: 600nMAssay Description:Inhibition of mouse endothelial lipase expressed in HEK293F cells using D31-POPC-HDL as substrate incubated for 2 hrs in presence of mouse plasma by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3QMNPubMed
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb Company

US Patent
LigandPNGBDBM319014(N-[(cyclopropyl- carbamoyl) methyl]-2-[6-(6- fluor...)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Inhibition of human endothelial lipase derived from human HT1080 cell conditioned media using PED-A1 as substrate incubated for 20 mins and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3QMNPubMed
TargetHepatic triacylglycerol lipase(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM319014(N-[(cyclopropyl- carbamoyl) methyl]-2-[6-(6- fluor...)copy SMILEScopy InChI
Affinity DataIC50: 79nMAssay Description:Inhibition of human hepatic lipase expressed in African green monkey COS7 cells using PED-A1 as substrate incubated for 20 mins and measured every 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3QMNPubMed
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb Company

US Patent
LigandPNGBDBM319014(N-[(cyclopropyl- carbamoyl) methyl]-2-[6-(6- fluor...)copy SMILEScopy InChI
Affinity DataIC50: 660nMAssay Description:Inhibition of human endothelial lipase using D31-POPC-HDL as substrate incubated for 2 hrs in presence of human serum by LC/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3QMNPubMed