null

SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(C)=O)[C@@H](C)O)C(O)=O

InChI Key InChIKey=GAFLTUQDNVDCCP-PRDVVYQQSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 415709   

TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM415709(Ac-LDEETGEFL-OH | US10442759, Compound Nrf2 9mer ...)copy SMILEScopy InChI
Affinity DataKi:  50nMAssay Description:Inhibition of recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3)pLysS cells by fluorescence polariza...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20R9SSFPubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM415709(Ac-LDEETGEFL-OH | US10442759, Compound Nrf2 9mer ...)copy SMILEScopy InChI
Affinity DataKi:  51nMAssay Description:Inhibition of Cys5-LDEETGEFL-NH2 binding to recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3) measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20R9SSFPubMed
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM415709(Ac-LDEETGEFL-OH | US10442759, Compound Nrf2 9mer ...)copy SMILEScopy InChI
Affinity DataKd:  23nMAssay Description:Binding affinity to recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3) by surface plasmon resonance ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20R9SSFPubMed
TargetKelch-like ECH-associated protein 1/Nuclear factor erythroid 2-related factor 2(Homo sapiens (Human))
CHINA PHARMACEUTICAL UNIVERSITY

US Patent
LigandPNGBDBM415709(Ac-LDEETGEFL-OH | US10442759, Compound Nrf2 9mer ...)copy SMILEScopy InChI
Affinity DataIC50: 330nMAssay Description:The instrument used in the FP experiment was the SpectraMax Multi-Mode Microplate Reader (Molecular Devices), and the excitation and emission wavelen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25D8V7TUS Patent
TargetKelch-like ECH-associated protein 1(Homo sapiens (Human))
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM415709(Ac-LDEETGEFL-OH | US10442759, Compound Nrf2 9mer ...)copy SMILEScopy InChI
Affinity DataEC50:  1.30E+4nMAssay Description:Binding affinity to recombinant human KEAP1 Kelch domain (321 to 609 residues) expressed in Escherichia coli BL21 (DE3) assessed as thermal stabiliza...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20R9SSFPubMed