null

SMILES COCc1nc2c(cc(NC(=O)c3c(Cl)cccc3C(F)(F)F)cc2[nH]1)C(=O)Nc1cccc(Cl)c1C

InChI Key InChIKey=CWUCHFDQGIOAID-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50028856   

TargetProstaglandin E synthase(Homo sapiens (Human))
NIPPON SHINYAKU CO., LTD.

US Patent
LigandPNGBDBM50028856(CHEMBL3342696 | US9216968, 113 | US9732066, 113)copy SMILEScopy InChI
Affinity DataKi:  0.100nM IC50: 0.100nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KS6QCQUS Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
NIPPON SHINYAKU CO., LTD.

US Patent
LigandPNGBDBM50028856(CHEMBL3342696 | US9216968, 113 | US9732066, 113)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human recombinant mPGES-1 expressed in CHO cells using PGH2 as substrate incubated for 10 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X068MNPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
NIPPON SHINYAKU CO., LTD.

US Patent
LigandPNGBDBM50028856(CHEMBL3342696 | US9216968, 113 | US9732066, 113)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:mPGES-1 microsome fractions were prepared from CHO-K1 cells transiently transfected with plasmid encoding the human mPGES-1cDNA. Microsomes were dilu...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K35WSWUS Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
NIPPON SHINYAKU CO., LTD.

US Patent
LigandPNGBDBM50028856(CHEMBL3342696 | US9216968, 113 | US9732066, 113)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human recombinant mPGES-1 expressed in CHO cells using PGH2 as substrate incubated for 10 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X068MNPubMed