null

SMILES C(Nc1nc(nc2ccccc12)-c1cccnc1)c1ccccc1

InChI Key InChIKey=AELMNLIYFALJIR-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50033284   

TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50033284(Benzyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine | CH...)copy SMILEScopy InChI
Affinity DataEC50: >3.00E+5nMAssay Description:Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TX3CTTPCBioAssay
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Biofor Inc.

Curated by ChEMBL
LigandPNGBDBM50033284(Benzyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine | CH...)copy SMILEScopy InChI
Affinity DataIC50: 450nMAssay Description:Inhibitory activity against phosphodiesterase 5 from human plateletsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F190CBPubMed
TargetThromboxane-A synthase(Homo sapiens (Human))
Biofor Inc.

Curated by ChEMBL
LigandPNGBDBM50033284(Benzyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine | CH...)copy SMILEScopy InChI
Affinity DataIC50: 5.80E+3nMAssay Description:In vitro inhibition of Thromboxane A2 synthase in human plateletMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F190CBPubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM50033284(Benzyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine | CH...)copy SMILEScopy InChI
Affinity DataIC50: 5.77E+3nMAssay Description:The enzyme in GCase enzyme activity buffer (25 μL/well) was added to a 384-well black plate. The fluorescent probe 3 (25 nL/well, 50 nM final co...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2862JH8US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM50033284(Benzyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine | CH...)copy SMILEScopy InChI
Affinity DataIC50: 5.77E+3nMpH: 5.9Assay Description:Inhibition of synthetic recombinant wild type GCase enzyme velaglucerase alfa (unknown origin) at pH 5.9 preincubated for 5 mins followed by addition...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QF8VV6PubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University

US Patent
LigandPNGBDBM50033284(Benzyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine | CH...)copy SMILEScopy InChI
Affinity DataIC50: 7.08E+3nMAssay Description:The enzyme in GCase enzyme activity buffer (25 μL/well) was added to a 384-well black plate. The fluorescent probe 3 (25 nL/well, 50 nM final co...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2862JH8US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Rattus norvegicus)
Biofor Inc.

Curated by ChEMBL
LigandPNGBDBM50033284(Benzyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine | CH...)copy SMILEScopy InChI
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of rat brain Phosphodiesterase 2More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2F190CBPubMed