null
SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)c2ccccc12
InChI Key InChIKey=UEJJHQNACJXSKW-UHFFFAOYSA-N
PDB links: 24 PDB IDs match this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 23 hits for monomerid = 50070114
TargetCereblon isoform 4(Magnetospirillum gryphiswaldense)
Max Planck Institute for Developmental Biology
Curated by ChEMBL
Max Planck Institute for Developmental Biology
Curated by ChEMBL
Affinity DataKi: 4.40E+3nMAssay Description:Inhibition of MANT-uracil binding to wild-type Magnetospirillum gryphiswaldense CRBN isoform 4 by FRET assayMore data for this Ligand-Target Pair
3D Structure (crystal)TargetCereblon isoform 4(Magnetospirillum gryphiswaldense)
Max Planck Institute for Developmental Biology
Curated by ChEMBL
Max Planck Institute for Developmental Biology
Curated by ChEMBL
Affinity DataKi: 4.40E+3nMAssay Description:Inhibition of MANT-uracil binding to wild type Magnetospirillum gryphiswaldense cereblon isoform 4 by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Affinity DataKi: 8.51E+3nMAssay Description:Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by measuring baseline corrected normalized fluorescence in pr...More data for this Ligand-Target Pair
Affinity DataKi: 2.27E+4nMAssay Description:Inhibition of MANT-uracil binding to human CRBN (delta 1 to 315) by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
TargetGranulocyte-macrophage colony-stimulating factor(Homo sapiens (Human))
Celgene Corporation
US Patent
Celgene Corporation
US Patent
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...More data for this Ligand-Target Pair
Affinity DataIC50: 370nMAssay Description:Inhibitory activity (RA1) of the compound against Prostaglandin G/H synthase 1 was calculated relative to aspirinMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibitory activity (RA2) of the compound against Prostaglandin G/H synthase 2 was calculated relative to aspirinMore data for this Ligand-Target Pair
TargetCereblon isoform 4(Magnetospirillum gryphiswaldense)
Max Planck Institute for Developmental Biology
Curated by ChEMBL
Max Planck Institute for Developmental Biology
Curated by ChEMBL
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of MANT-uracil binding to wild type Magnetospirillum gryphiswaldense cereblon isoform 4 by FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.99E+4nMAssay Description:Inhibition of MANT-uracil binding to human CRBN (delta 1 to 315) by FRET assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Celgene Corporation
Curated by ChEMBL
Celgene Corporation
Curated by ChEMBL
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of PDE4 enzyme from U937 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
Affinity DataIC50: 2.29E+4nMAssay Description:Binding affinity to human CRBN-thalidomide binding domain expressed in Escherichia coli by measuring baseline corrected normalized fluorescence in pr...More data for this Ligand-Target Pair
Affinity DataIC50: 301nMAssay Description:A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...More data for this Ligand-Target Pair
Affinity DataIC50: 268nMAssay Description:A thalidomide competition AlphaScreen assay was employed to measure the binding affinity (IC50) of thalidomide conjugates and novel IMiDs to CRBN-DDB...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...More data for this Ligand-Target Pair
TargetGlyceraldehyde-3-phosphate dehydrogenase, cytosolic(Leishmania mexicana)
Celgene Corporation
US Patent
Celgene Corporation
US Patent
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMpH: 8.0 T: 2°CAssay Description:Thermal stabilities of CRBN-DDB1 in the presence or absence of phthalimide, thalidomide, lenalidomide and pomalidomide were done in the presence of S...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMT: 2°CAssay Description:The Fix buffer I was warmed up to 37° C. in an incubator or water bath prior to use. The Perm Buffer III was chilled in a ⿿20° C. freezer p...More data for this Ligand-Target Pair