null

SMILES COC(=O)N[C@@H]1Cc2ccc(NC(=O)c3cccc(C)c3-c3ccc(cc3)C(F)(F)F)cc2C1

InChI Key InChIKey=JKHYOWBRQRJSTQ-OAQYLSRUSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50107789   

TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Novartis Institute for Biomedical Reasearch

Curated by ChEMBL
LigandPNGBDBM50107789((R)-methyl 5-(6-methyl-4'-(trifluoromethyl)bipheny...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:In vitro inhibitory activity against MTP using MTP transfer assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23F4NXHPubMed
TargetApolipoprotein B-100(Homo sapiens (Human))
Novartis Institute for Biomedical Reasearch

Curated by ChEMBL
LigandPNGBDBM50107789((R)-methyl 5-(6-methyl-4'-(trifluoromethyl)bipheny...)copy SMILEScopy InChI
Affinity DataIC50: 6.40nMAssay Description:Inhibition of apolipoprotein B (apoB) secreted by human hepatoma cells (Hep G2) at 100 nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23F4NXHPubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50107789((R)-methyl 5-(6-methyl-4'-(trifluoromethyl)bipheny...)copy SMILEScopy InChI
Affinity DataIC50: 3.42E+3nMAssay Description:Antagonist activity at human Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29887ZNPubMed
TargetSmoothened homolog(Mus musculus)
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50107789((R)-methyl 5-(6-methyl-4'-(trifluoromethyl)bipheny...)copy SMILEScopy InChI
Affinity DataIC50: 2.48E+3nMAssay Description:Antagonist activity at mouse Smo receptor expressed in CHO cells by [3H]Hh-Ag binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29887ZNPubMed
TargetMicrosomal triglyceride transfer protein large subunit(Homo sapiens (Human))
Novartis Institute for Biomedical Reasearch

Curated by ChEMBL
LigandPNGBDBM50107789((R)-methyl 5-(6-methyl-4'-(trifluoromethyl)bipheny...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:Inhibition of MTP in human HepG2 cells assessed as apolipoprotein B production by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29887ZNPubMed