null

SMILES CCn1c2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2cc(-c2ccc(cc2Cl)-c2cncs2)c1=O

InChI Key InChIKey=DHUJCQOUWQMVCG-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50112347   

TargetSerine/threonine-protein kinase PAK 1 [249-545,K299R](Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)copy SMILEScopy InChI
Affinity DataIC50: 7.70nMAssay Description:IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 2(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)copy SMILEScopy InChI
Affinity DataIC50: 12.8nMAssay Description:IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)copy SMILEScopy InChI
Affinity DataIC50: 19.3nMAssay Description:IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:IC50 values were determined using a 10 concentration point, non-radioactive, functional assay that employs a fluorescence-based, coupled enzyme forma...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27T4SPubMed
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)copy SMILEScopy InChI
Affinity DataIC50: 7.70nMAssay Description:Inhibition of recombinant human PAK1 by Z'-LYTE assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human PAK4 by Z'-LYTE assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X2BQSPubMed
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 2(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant human PAK2 by Z'-LYTE assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)copy SMILEScopy InChI
Affinity DataIC50: 88nMAssay Description:Inhibition of PAK1 phosphorylation in human MCF10A cellsMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMAssay Description:Inhibition of PAK1 (unknown origin) by ATP-kinaseGlo assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of PAK1 (unknown origin) using lipid substrate measured after 40 mins by ADP-glo kinase assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 2(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of PAK2 (unknown origin) using lipid substrate measured after 40 mins by ADP-glo kinase assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of PAK3 (unknown origin) using lipid substrate measured after 40 mins by ADP-glo kinase assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 3(Homo sapiens (Human))
The Scripps Research Institute

LigandPNGBDBM50112347(CHEMBL3609327 | FRAX597)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant human PAK3 by Z'-LYTE assayMore data for this Ligand-Target Pair