null
SMILES CCCN[C@H]1CCc2nc(N)sc2C1
InChI Key InChIKey=FASDKYOPVNHBLU-ZETCQYMHSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 104 hits for monomerid = 50116766
Affinity DataKi: 0.450nMAssay Description:Displacement of [3H]R(+)-7-OH-DPAT from Sprague-Dawley rat dopamine D3 receptor after 90 minsMore data for this Ligand-Target Pair
Affinity DataKi: 0.780nMAssay Description:Displacement of [3H]-R(+)-7-OHDPAT from dopamine D3 receptor in rat brain homogenatesMore data for this Ligand-Target Pair
Affinity DataKi: 0.780nMAssay Description:Displacement of [3H]PD128907 from dopamine D3 receptor in Sprague-Dawley rat ventral striatumMore data for this Ligand-Target Pair
Affinity DataKi: 0.870nMAssay Description:Binding affinity of compound measured using [3H]-spiperone for the cloned human dopamine receptor D2 long (high/low affinity is given as 9.0/1800)More data for this Ligand-Target Pair
Affinity DataKi: 0.880nMAssay Description:High inhibition constant against [3H]-spiperone binding to human Dopamine receptor D3 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 0.880nMAssay Description:High binding affinity towards human dopamine receptor 3 expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 0.900nMAssay Description:Displacement of [3H]-N-methylspiperone from D3 receptor (unknown origin) measured after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 0.940nMAssay Description:Displacement of [3H]-7-OH-DPAT from human D3R expressed in HEK293 cell membranes measured after 90 mins in Tris buffer by topcount assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.10nMAssay Description:Displacement of [3H]-7-OH-DPAT from human D3R expressed in HEK293 cell membranes measured after 90 mins in EBSS buffer by topcount assayMore data for this Ligand-Target Pair
Affinity DataKi: 1.30nMAssay Description:Displacement of [3H]-(R)-(+)-7-OH-DPAT from recombinant human D3 receptor expressed in HEK293 cell membranes measured after 90 mins by microbeta scin...More data for this Ligand-Target Pair
Affinity DataKi: 3.10nMAssay Description:Displacement of [3H]Spiperone from D2 receptor in Sprague-Dawley rat caudate-putamenMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
Affinity DataKi: 4.70nMAssay Description:Displacement of [3H]-methylspiperon from human D2RL expressed in HEK293 cell membranes measured after 90 mins by topcount assayMore data for this Ligand-Target Pair
Affinity DataKi: 5.60nMAssay Description:Displacement of [3H]-7-OH-DPAT from human D3R expressed in HEK293 cell membranes measured after 90 mins in Tris buffer containing NaCl by topcount as...More data for this Ligand-Target Pair
Affinity DataKi: 8.10nMAssay Description:High inhibition constant against [3H]-spiperone binding to human Dopamine receptor D4.4 expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 8.10nMAssay Description:High binding affinity towards human dopamine receptor 4.4 expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 8.20nMAssay Description:Displacement of [3H]-methylspiperon from human D3R expressed in HEK293 cell membranes measured after 90 mins in EBSS buffer by topcount assayMore data for this Ligand-Target Pair
Affinity DataKi: 8.5nMAssay Description:Binding affinity of compound measured using [3H]-spiperone for the cloned human Dopamine receptor D3 (high/low affinity is given as 25/1600)More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
Affinity DataKi: 11nMAssay Description:Displacement of [3H]-(R)-(+)-7-OH-DPAT from recombinant human D2L receptor expressed in HEK293 cell membranes measured after 90 mins by microbeta sci...More data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Displacement of [3H]-methylspiperon from human D3R expressed in HEK293 cell membranes measured after 90 mins in Tris buffer by topcount assayMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Displacement of [3H]-methylspiperon from human D3R expressed in HEK293 cell membranes measured after 90 mins in Tris buffer containing NaCl by topcou...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
Affinity DataKi: 21nMAssay Description:High binding affinity towards human dopamine receptor 2 (long) expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligandMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
Affinity DataKi: 21nMAssay Description:High binding affinity towards human dopamine receptor 2 (short) expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligandMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
Affinity DataKi: 21nMAssay Description:High inhibition constant against [3H]-spiperone binding to human Dopamine receptor D2L expressed in CHO cellsMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
Affinity DataKi: 21nMAssay Description:High inhibition constant against [3H]-spiperone binding to human Dopamine receptor D2S expressed in CHO cellsMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
Affinity DataKi: 27nMAssay Description:Binding affinity of compound measured using [3H]-spiperone for the cloned human dopamine receptor D2 long (high/low affinity is given as 27/5400)More data for this Ligand-Target Pair
Affinity DataKi: 29nMAssay Description:Displacement of [3H]-N-methylspiperone from recombinant human D4 receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta ...More data for this Ligand-Target Pair
Affinity DataKi: 38nMAssay Description:Low binding affinity towards human dopamine receptor 3 expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 38nMAssay Description:Low inhibition constant against [3H]-spiperone binding to human Dopamine receptor D3 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
Affinity DataKi: 40nMAssay Description:Binding affinity of compound measured using [3H]-spiperone for the cloned human dopamine receptor D4.4 (high/low affinity is given as 8.5/130)More data for this Ligand-Target Pair
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
Affinity DataKi: 52nMAssay Description:Displacement of [3H]-rauwolscine from recombinant human alpha2C adrenergic receptor stably expressed in MDCK cell membranes measured after 90 mins by...More data for this Ligand-Target Pair
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
Affinity DataKi: 68nMAssay Description:Displacement of [3H]-rauwolscine from recombinant human alpha2B adrenergic receptor transiently expressed in HEKT cell membranes measured after 90 mi...More data for this Ligand-Target Pair
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
Affinity DataKi: 76nMAssay Description:Displacement of [3H]-rauwolscine from recombinant human alpha2A adrenergic receptor stably expressed in MDCK cell membranes measured after 90 mins by...More data for this Ligand-Target Pair
Affinity DataKi: 130nMAssay Description:Low binding affinity towards human dopamine receptor 4.4 expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligandMore data for this Ligand-Target Pair
Affinity DataKi: 130nMAssay Description:Low inhibition constant against [3H]-spiperone binding to human Dopamine receptor D4.4 expressed in CHO cellsMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
Affinity DataKi: 744nMAssay Description:Displacement of [3H]-N-methylspiperone from recombinant human D2 receptor stably expressed in fibroblast cell membranes measured after 90 mins by mic...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
Affinity DataKi: 1.19E+3nMAssay Description:Displacement of [3H]-LSD from recombinant human 5HT7A receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillati...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
Affinity DataKi: 1.90E+3nMAssay Description:Low binding affinity towards human dopamine receptor 2 (short) expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligandMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
Affinity DataKi: 1.90E+3nMAssay Description:Low inhibition constant against [3H]-spiperone binding to human Dopamine receptor D2S expressed in CHO cellsMore data for this Ligand-Target Pair
TargetHistamine H2 receptor(Homo sapiens (Human))
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
Affinity DataKi: 2.68E+3nMAssay Description:Displacement of [125I]-Iodo-aminopotentidine from human histamine H2 receptor expressed in stable HEK cell membranes after 90 mins by microbeta scint...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
Affinity DataKi: 3.51E+3nMAssay Description:Displacement of [3H]5-CT from recombinant human 5HT1B receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillati...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
Affinity DataKi: 4.45E+3nMAssay Description:Displacement of [3H]-pentazocine from sigma1 receptor (unknown origin) after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
Affinity DataKi: 6.30E+3nMAssay Description:Low binding affinity towards human dopamine receptor 2 (long) expressed in Chinese hamster ovary cells using [3H]spiperone (0.5 nM) as radioligandMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
Affinity DataKi: 6.30E+3nMAssay Description:Low inhibition constant against [3H]-spiperone binding to human Dopamine receptor D2L expressed in CHO cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
Affinity DataKi: 6.51E+3nMAssay Description:Displacement of [3H]-Way100635 from recombinant human 5HT1A receptor stably expressed in CHO cell membranes measured after 90 mins by microbeta scint...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-LSD from recombinant human 5HT6 receptor stably expressed in HEK cell membranes measured after 90 mins by microbeta scintillatio...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 5A(Homo sapiens (Human))
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-LSD from recombinant human 5HT5A receptor stably expressed in Flp-In CHO cell membranes measured after 90 mins by microbeta scin...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
National Institute of Neurological Disorders and Stroke
Curated by ChEMBL
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]5-CT from recombinant human 5HT1D receptor transiently expressed in HEKT cell membranes measured after 90 mins by microbeta scint...More data for this Ligand-Target Pair