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SMILES COc1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1

InChI Key InChIKey=XLTFNNCXVBYBSX-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50140257   

TargetPyruvate kinase PKM(Homo sapiens (Human))TBA
LigandPNGBDBM50140257(5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one | 5...)copy SMILEScopy InChI
Affinity DataKi:  3.53E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330SPPubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))TBA
LigandPNGBDBM50140257(5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one | 5...)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:In vitro antagonism of the 5-HT-3 receptor determined by inhibition of 5-HT-induced depolarization of the isolated rat vagus nerve.More data for this Ligand-Target Pair
In DepthDetails
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Guru Nanak Dev University

Curated by ChEMBL
LigandPNGBDBM50140257(5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one | 5...)copy SMILEScopy InChI
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of human recombinant COX-2 assessed as PGF2 alpha formation using arachidonic acid as substrate pretreated with compound for 20 mins prior...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N87CJNPubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
University of Medicine and Pharmacy at Ho Chi Minh City

Curated by ChEMBL
LigandPNGBDBM50140257(5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one | 5...)copy SMILEScopy InChI
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of COX2-mediated PGE2 production in LPS-stimulated mouse RAW264.7 cells by enzyme immunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28052HJPubMed
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50140257(5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one | 5...)copy SMILEScopy InChI
Affinity DataIC50: 1.76E+5nMAssay Description:Inhibition of cow milk xanthine oxidaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5FNNPubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Guru Nanak Dev University

Curated by ChEMBL
LigandPNGBDBM50140257(5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one | 5...)copy SMILEScopy InChI
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of COX2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27S7PN5PubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Kangwon National University

Curated by ChEMBL
LigandPNGBDBM50140257(5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one | 5...)copy SMILEScopy InChI
Affinity DataIC50: 7.80E+3nMAssay Description:Inhibition of iNOS-induced NO production in LPS-stimulated mouse BV2 cells after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q52QNTPubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50140257(5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one | 5...)copy SMILEScopy InChI
Affinity DataIC50: 8.87E+3nMAssay Description:Inhibition of LSD1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8J40PubMed
TargetTrypsin(Homo sapiens (Human))
Ehime University

Curated by ChEMBL
LigandPNGBDBM50140257(5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one | 5...)copy SMILEScopy InChI
Affinity DataIC50: 1.05E+5nMAssay Description:Inhibition of trypsin-induced elevation in PAI1 production in HUVEC by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C4ZK4PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50140257(5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one | 5...)copy SMILEScopy InChI
Affinity DataIC50: 198nMAssay Description:Inhibition of human CDK9/cyclin-T1 using YSPTSPSYSPTSPSYSPTSPKKK peptide as substrate after 2 hrs by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP789WPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50140257(5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one | 5...)copy SMILEScopy InChI
Affinity DataIC50: 1.46E+3nMAssay Description:Inhibition of human CDK2/cyclin-A2 using H1 histone as substrate after 2 hrs by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP789WPubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50140257(5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one | 5...)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged CDK9 (2 to 372 residues)/N-terminal GST-tagged cyclin-T1 (2 to 726 residues) expressed in bacul...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XP789WPubMed
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50140257(5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one | 5...)copy SMILEScopy InChI
Affinity DataIC50: 1.23E+4nMAssay Description:Inhibition of recombinant human full length C-terminal His6-tagged and N-terminal GST-tagged CDK7/cyclinH/MAT1 expressed in baculovirus Sf21 insect c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9TG4PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50140257(5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one | 5...)copy SMILEScopy InChI
Affinity DataIC50: 1.46E+3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9TG4PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50140257(5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one | 5...)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:Inhibition of human recombinant N-terminal GST-tagged CDK9 (2 to 372 residues) expressed in baculovirus infected Sf9 insect cells co-expressing human...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9TG4PubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))TBA
LigandPNGBDBM50140257(5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one | 5...)copy SMILEScopy InChI
Affinity DataIC50: 2.01E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330SPPubMed
TargetCyclin-C(Homo sapiens (Human))TBA
LigandPNGBDBM50140257(5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one | 5...)copy SMILEScopy InChI
Affinity DataIC50: 5.90E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FT8R4VPubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))TBA
LigandPNGBDBM50140257(5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one | 5...)copy SMILEScopy InChI
Affinity DataIC50: 190nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6QH4PubMed
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Tom's of Maine

Curated by ChEMBL
LigandPNGBDBM50140257(5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one | 5...)copy SMILEScopy InChI
Affinity DataIC50: 3.50E+5nMAssay Description:Displacement of [3H]LSD from human 5HT7 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ36WZPubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Guru Nanak Dev University

Curated by ChEMBL
LigandPNGBDBM50140257(5,7-Dihydroxy-8-methoxy-2-phenyl-chromen-4-one | 5...)copy SMILEScopy InChI
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of human recombinant COX-2 assessed as decrease in prostaglandin production using arachidonic acid as substrate incubated with enzyme for ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2319XH6PubMed