null

SMILES CN1CCC(O)(CC1)c1cn(c(n1)-c1cccc(c1)C(F)(F)F)-c1ccnc(NC2CCCC2)n1

InChI Key InChIKey=NTPLIHVIDFWRGV-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50148694   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50148694(4-[1-(2-Cyclopentylamino-pyrimidin-4-yl)-2-(3-trif...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69J2CPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50148694(4-[1-(2-Cyclopentylamino-pyrimidin-4-yl)-2-(3-trif...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human c-SrcMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69J2CPubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50148694(4-[1-(2-Cyclopentylamino-pyrimidin-4-yl)-2-(3-trif...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibition of human prostaglandin G/H synthase 1, COX-1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69J2CPubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50148694(4-[1-(2-Cyclopentylamino-pyrimidin-4-yl)-2-(3-trif...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human cytochrome P450 2C9More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69J2CPubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50148694(4-[1-(2-Cyclopentylamino-pyrimidin-4-yl)-2-(3-trif...)copy SMILEScopy InChI
Affinity DataIC50: 4.66E+3nMAssay Description:Inhibition of human c-Jun N-terminal kinase 2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69J2CPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50148694(4-[1-(2-Cyclopentylamino-pyrimidin-4-yl)-2-(3-trif...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human RAF proto-oncogene serine/threonine-protein kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69J2CPubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50148694(4-[1-(2-Cyclopentylamino-pyrimidin-4-yl)-2-(3-trif...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human cyclin-dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69J2CPubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50148694(4-[1-(2-Cyclopentylamino-pyrimidin-4-yl)-2-(3-trif...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human c-Kit kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69J2CPubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50148694(4-[1-(2-Cyclopentylamino-pyrimidin-4-yl)-2-(3-trif...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69J2CPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50148694(4-[1-(2-Cyclopentylamino-pyrimidin-4-yl)-2-(3-trif...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human cytochrome P450 3A4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69J2CPubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50148694(4-[1-(2-Cyclopentylamino-pyrimidin-4-yl)-2-(3-trif...)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Inhibition of murine phosphorylated His-Mitogen-activated protein kinase p38 alpha.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69J2CPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50148694(4-[1-(2-Cyclopentylamino-pyrimidin-4-yl)-2-(3-trif...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Epidermal growth factor receptor, HER-1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69J2CPubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50148694(4-[1-(2-Cyclopentylamino-pyrimidin-4-yl)-2-(3-trif...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human c-Jun N-terminal kinase 1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69J2CPubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50148694(4-[1-(2-Cyclopentylamino-pyrimidin-4-yl)-2-(3-trif...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human insulin-like growth factor I receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69J2CPubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50148694(4-[1-(2-Cyclopentylamino-pyrimidin-4-yl)-2-(3-trif...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human cytochrome P450 1A2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69J2CPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50148694(4-[1-(2-Cyclopentylamino-pyrimidin-4-yl)-2-(3-trif...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69J2CPubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50148694(4-[1-(2-Cyclopentylamino-pyrimidin-4-yl)-2-(3-trif...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Met proto-oncogene tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69J2CPubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50148694(4-[1-(2-Cyclopentylamino-pyrimidin-4-yl)-2-(3-trif...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human c-AblMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69J2CPubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50148694(4-[1-(2-Cyclopentylamino-pyrimidin-4-yl)-2-(3-trif...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human HER-2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69J2CPubMed