null
SMILES COc1cccc(OC)c1CNC(=O)c1cc(ccc1F)C1NC(=O)NC(C)=C1C(=O)Nc1ccc2[nH]ncc2c1
InChI Key InChIKey=KQJWWWZXJNOLQF-UHFFFAOYSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50173319
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GRK5 (unknown origin) using tubulin as substrate by SDS-PAGE methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GRK1 (unknown origin) using tubulin as substrate by SDS-PAGE methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
US Patent
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
US Patent
Affinity DataIC50: 130nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair
3D Structure (crystal)TargetBeta-adrenergic receptor kinase 1(Bos taurus)
Department of Medicinal Chemistry, College of Pharmacy,?Departments of Pharmacology and Biological Chemistry, Life Sciences Institute,§Ph.D. Program in Chemical Biology,?Vahlteich Medicinal Chemistry
Curated by ChEMBL
Department of Medicinal Chemistry, College of Pharmacy,?Departments of Pharmacology and Biological Chemistry, Life Sciences Institute,§Ph.D. Program in Chemical Biology,?Vahlteich Medicinal Chemistry
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of bovine GRK2 S670A mutant after 5 mins in presence of ATP by phosphorimaging assayMore data for this Ligand-Target Pair
TargetRho-associated protein kinase 1(Homo sapiens (Human))
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
US Patent
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
US Patent
Affinity DataIC50: 1.00E+4nMAssay Description:Rho-associated coiled-coil kinase (ROCK) assays were performed with the ADP-Glo system using 0.1 μg ROCK1 and 1 μg S6K substrate, and 100 &...More data for this Ligand-Target Pair
TargetRhodopsin kinase GRK1(Bos taurus)
Department of Medicinal Chemistry, College of Pharmacy,?Departments of Pharmacology and Biological Chemistry, Life Sciences Institute,§Ph.D. Program in Chemical Biology,?Vahlteich Medicinal Chemistry
Curated by ChEMBL
Department of Medicinal Chemistry, College of Pharmacy,?Departments of Pharmacology and Biological Chemistry, Life Sciences Institute,§Ph.D. Program in Chemical Biology,?Vahlteich Medicinal Chemistry
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory concentration against alpha-galactosidase of coffee beanMore data for this Ligand-Target Pair
TargetBeta-adrenergic receptor kinase 1(Homo sapiens (Human))
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
US Patent
THE REGENTS OF THE UNIVERSITY OF MICHIGAN
US Patent
Affinity DataIC50: 130nMAssay Description:Inhibition of GRK2 (unknown origin)More data for this Ligand-Target Pair
TargetG protein-coupled receptor kinase 5(Bos taurus)
Department of Medicinal Chemistry, College of Pharmacy,?Departments of Pharmacology and Biological Chemistry, Life Sciences Institute,§Ph.D. Program in Chemical Biology,?Vahlteich Medicinal Chemistry
Curated by ChEMBL
Department of Medicinal Chemistry, College of Pharmacy,?Departments of Pharmacology and Biological Chemistry, Life Sciences Institute,§Ph.D. Program in Chemical Biology,?Vahlteich Medicinal Chemistry
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Binding affinity of compound towards dopamine transporter determined using [3H]WIN-35 428 as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMpH: 7.0Assay Description:GRK1, 2 and 5 kinetic assays were conducted in a buffer containing 20 mM HEPES pH 7.0, 5 μM ATP, 2 mM MgCl2, and 0.025% DDM with 50 nM GRK and e...More data for this Ligand-Target Pair