null
SMILES CC(=O)Nc1cccc(c1)N1CCN(CCCCNS(=O)(=O)CC2CCCCC2)CC1
InChI Key InChIKey=SPWZXWDPAWDKQE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 34 hits for monomerid = 50187377
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: 5.10nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor in HEK293 cellsMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: 17nMAssay Description:Binding affinity to 5HT1A receptor in rat cerebral cortex by radioligand binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: 30nMAssay Description:Binding affinity to 5HT1A receptor in rat cortex membraneMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: 100nMAssay Description:Binding affinity to guinea pig sigma receptor by radioligand binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 7(Homo sapiens (Human))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: 700nMAssay Description:Binding affinity to 5HT7 receptor by radioligand binding assayMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: 1.60E+3nMAssay Description:Displacement of [3H]prazosin from adrenergic alpha-1 receptor in rat cerebral cortex cellsMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: >2.00E+3nMAssay Description:Binding affinity to potassium channel by radioligand binding assayMore data for this Ligand-Target Pair
TargetCholecystokinin receptor type A/Gastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: >2.00E+3nMAssay Description:Binding affinity to cholecystokinin receptor by radioligand binding assayMore data for this Ligand-Target Pair
TargetSomatostatin receptor type 1/2/3/4/5(Homo sapiens (Human))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: >2.00E+3nMAssay Description:Binding affinity to somatostatin receptor by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: >2.00E+3nMAssay Description:Binding affinity to orphanin receptor by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: >2.00E+3nMAssay Description:Binding affinity to D2 receptor by radioligand binding assayMore data for this Ligand-Target Pair
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: >2.00E+3nMAssay Description:Binding affinity to dopamine transporter by radioligand binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: >2.00E+3nMAssay Description:Binding affinity to 5HT1B receptor in rat cerebral cortex by radioligand binding assayMore data for this Ligand-Target Pair
TargetBeta-1/Beta-2/Beta-3 adrenergic receptor(Homo sapiens (Human))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: >2.00E+3nMAssay Description:Binding affinity to beta adrenergic receptor by radioligand binding assayMore data for this Ligand-Target Pair
TargetType-1/Type-2 angiotensin II receptor(Homo sapiens (Human))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: >2.00E+3nMAssay Description:Binding affinity to angiotensin2 receptor by radioligand binding assayMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Homo sapiens (Human))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: >2.00E+3nMAssay Description:Binding affinity to dopamine receptor by radioligand binding assayMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Homo sapiens (Human))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: >2.00E+3nMAssay Description:Binding affinity to muscarinic receptor by radioligand binding assayMore data for this Ligand-Target Pair
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Homo sapiens (Human))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: >2.00E+3nMAssay Description:Binding affinity to opioid receptor by radioligand binding assayMore data for this Ligand-Target Pair
Affinity DataKi: >2.00E+3nMAssay Description:Binding affinity to benzodiazepine receptor by radioligand binding assayMore data for this Ligand-Target Pair
TargetEndothelin receptor type B/1 receptor(Homo sapiens (Human))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: >2.00E+3nMAssay Description:Binding affinity to endothelin receptor by radioligand binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: >2.00E+3nMAssay Description:Binding affinity to 5HT2A receptor by radioligand binding assayMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: >2.00E+3nMAssay Description:Binding affinity to sigma receptor by radioligand binding assayMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: >2.00E+3nMAssay Description:Binding affinity to norepinephrine transporter by radioligand binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: >2.00E+3nMAssay Description:Binding affinity to bovine 5HT1D receptor by radioligand binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity to human 5HT4e receptor by radioligand binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 5A(Homo sapiens (Human))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity to human 5HT5A receptor by radioligand binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity to human 5HT2C receptor by radioligand binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 3A/3B(Mus musculus (house mouse))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity to mouse 5HT3 receptor by radioligand binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity to human 5HT6 receptor by radioligand binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataKi: >5.00E+3nMAssay Description:Binding affinity to 5HT2B receptor by radioligand binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataEC50: 20nMAssay Description:Activity against 5HT1A receptor by Gi-[35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of hERG potassium channel in HEK293 cells by patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Predix Pharmaceuticals Ltd.
Curated by ChEMBL
Affinity DataEC50: 93nMAssay Description:Agonist activity at human 5HT1A receptor expressed in C6 cells assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair