null
SMILES Cc1cnc(Cl)nc1-c1ccc(cc1)N(Cc1ccc(CNC(=O)C(F)F)cc1)C(=O)c1ccc(O)cc1O
InChI Key InChIKey=LCGNLQSOSJFLKR-UHFFFAOYSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 22 hits for monomerid = 50236530
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
Vernalis (R&D) Ltd.
Curated by ChEMBL
Vernalis (R&D) Ltd.
Curated by ChEMBL
Affinity DataKi: 28nMAssay Description:Inhibition of fluorescein-labelled VER160364 binding to PDHK1 (unknown origin) after 90 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of fluorescein-labelled VER160364 from HSP90A (unknown origin) after 90 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial(Homo sapiens (Human))
Vernalis (R&D) Ltd.
Curated by ChEMBL
Vernalis (R&D) Ltd.
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of PDHK3 (unknown origin) assessed as decrease in phosphorylation of E1alpha subunit at serine 293 residue after 1 hr by DELFIAMore data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
Vernalis (R&D) Ltd.
Curated by ChEMBL
Vernalis (R&D) Ltd.
Curated by ChEMBL
Affinity DataKd: 150nMAssay Description:Inhibition of [3H]WIN-35428 binding to dopamine transporter (DAT) of cynomolgus monkey caudate-putamenMore data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
Vernalis (R&D) Ltd.
Curated by ChEMBL
Vernalis (R&D) Ltd.
Curated by ChEMBL
Affinity DataIC50: 84nMAssay Description:Inhibition of PDHK2 (unknown origin) assessed as decrease in phosphorylation of E1alpha subunit at serine 293 residue after 1 hr by DELFIAMore data for this Ligand-Target Pair
3D Structure (crystal)Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial(Homo sapiens (Human))
Vernalis (R&D) Ltd.
Curated by ChEMBL
Vernalis (R&D) Ltd.
Curated by ChEMBL
Affinity DataIC50: 91nMAssay Description:Inhibition of PDHK4 (unknown origin) assessed as decrease in phosphorylation of E1alpha subunit at serine 293 residue after 1 hr by DELFIAMore data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial(Homo sapiens (Human))
Vernalis (R&D) Ltd.
Curated by ChEMBL
Vernalis (R&D) Ltd.
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of PDHK4 (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
Vernalis (R&D) Ltd.
Curated by ChEMBL
Vernalis (R&D) Ltd.
Curated by ChEMBL
Affinity DataIC50: 42nMAssay Description:Inhibition of PDHK1 (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha/90-beta(Homo sapiens (Human))
Korea University
Curated by ChEMBL
Korea University
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HSP90 (unknown origin)More data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
Vernalis (R&D) Ltd.
Curated by ChEMBL
Vernalis (R&D) Ltd.
Curated by ChEMBL
Affinity DataIC50: 65nMAssay Description:Inhibition of PDHK2 (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial(Homo sapiens (Human))
Vernalis (R&D) Ltd.
Curated by ChEMBL
Vernalis (R&D) Ltd.
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Inhibition of PDHK3 (unknown origin) by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial(Homo sapiens (Human))
Vernalis (R&D) Ltd.
Curated by ChEMBL
Vernalis (R&D) Ltd.
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human His-tagged PDK3 expressed in Escherichia coli using PDH E1 as substrate measured after 30 mins by Kinase-Glo luminesc...More data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
Vernalis (R&D) Ltd.
Curated by ChEMBL
Vernalis (R&D) Ltd.
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of recombinant human His-tagged PDK1 expressed in Escherichia coli using PDH E1 as substrate measured after 30 mins by Kinase-Glo luminesc...More data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
Vernalis (R&D) Ltd.
Curated by ChEMBL
Vernalis (R&D) Ltd.
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant human His-tagged PDK2 expressed in Escherichia coli using PDH E1 as substrate measured after 30 mins by Kinase-Glo luminesc...More data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial(Homo sapiens (Human))
Vernalis (R&D) Ltd.
Curated by ChEMBL
Vernalis (R&D) Ltd.
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of recombinant human His-tagged PDK2 expressed in Escherichia coli using PDH E1 as substrate measured after 30 mins by Kinase-Glo luminesc...More data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
Vernalis (R&D) Ltd.
Curated by ChEMBL
Vernalis (R&D) Ltd.
Curated by ChEMBL
Affinity DataIC50: 90nMAssay Description:Inhibition of recombinant human His-tagged PDK1 expressed in Escherichia coli using PDH E1 as substrate measured after 30 mins by Kinase-Glo luminesc...More data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial(Homo sapiens (Human))
Vernalis (R&D) Ltd.
Curated by ChEMBL
Vernalis (R&D) Ltd.
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of recombinant human His-tagged PDK3 expressed in Escherichia coli using PDH E1 as substrate measured after 30 mins by Kinase-Glo luminesc...More data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial(Homo sapiens (Human))
Vernalis (R&D) Ltd.
Curated by ChEMBL
Vernalis (R&D) Ltd.
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of recombinant human His-tagged PDK4 expressed in Escherichia coli using PDH E1 as substrate measured after 30 mins by Kinase-Glo luminesc...More data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial(Homo sapiens (Human))
Vernalis (R&D) Ltd.
Curated by ChEMBL
Vernalis (R&D) Ltd.
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of recombinant human His-tagged PDK4 expressed in Escherichia coli using PDH E1 as substrate measured after 30 mins by Kinase-Glo luminesc...More data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
Vernalis (R&D) Ltd.
Curated by ChEMBL
Vernalis (R&D) Ltd.
Curated by ChEMBL
Affinity DataIC50: 573nMAssay Description:Inhibition of PDHK1 in human PC3 cells assessed as decrease in phosphorylation of E1alpha subunit at serine 293 residue after 1 hr by ELISAMore data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
Vernalis (R&D) Ltd.
Curated by ChEMBL
Vernalis (R&D) Ltd.
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant PDHK1 co-complexed with porcine PDH using sodium pyruvate, coenzymeA and NAD as substrates preincubated with enzyme c...More data for this Ligand-Target Pair
Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Homo sapiens (Human))
Vernalis (R&D) Ltd.
Curated by ChEMBL
Vernalis (R&D) Ltd.
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Binding affinity towards human Dopamine receptor D2 (short) by [3H]-spiperone displacement.More data for this Ligand-Target Pair