null

SMILES Cc1cncc(Oc2sc(C(N)=O)c3CCc4cnsc4-c23)c1

InChI Key InChIKey=WNVQODMEPIULDK-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50248639   

TargetCyclin-C/Cyclin-dependent kinase 19(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50248639(CHEMBL4072372)copy SMILEScopy InChI
Affinity DataIC50: 9.20nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK19/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9D6HPubMed
TargetCyclin-C(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50248639(CHEMBL4072372)copy SMILEScopy InChI
Affinity DataIC50: 5.10nMAssay Description:Inhibition of kinase tracer-236 binding to GST-tagged CDK8/CyclinC (unknown origin) after 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9D6HPubMed
TargetCyclin-dependent kinase 8(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50248639(CHEMBL4072372)copy SMILEScopy InChI
Affinity DataEC50:  28nMAssay Description:Inhibition of CDK8 in human SW620 cells assessed as decrease in STAT1 phosphorylation at Ser727 after 2 hrs by Western blot methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9D6HPubMed