null

SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1

InChI Key InChIKey=SWDINMTYJOBJBL-UHFFFAOYSA-N

PDB links: 4 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 41 hits for monomerid = 50279080   

TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of PDGFRbeta (unknown origin) using poly (Glu, Tyr)4:1 as substrate by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27WQ7PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75JSPubMed
TargetInsulin receptor(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human insulin receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3715PubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of human VEGFR3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3715PubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3715PubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75JSPubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:Inhibition of human VEGFR1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3715PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of human GST-fused VEGFR2 expressed in Sf9 insect cells after 20 mins by scintillation countingMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Mus musculus)
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of mouse GST-fused VEGFR2 expressed in Sf9 insect cells after 20 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3715PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 69nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3715PubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:Inhibition of human FGFR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3715PubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 108nMAssay Description:Inhibition of human FGFR3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3715PubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 610nMAssay Description:Inhibition of human FGFR4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3715PubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 59nMAssay Description:Inhibition of human PDGFRalphaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3715PubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
East China University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 65nMAssay Description:Inhibition of human PDGFRbetaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3715PubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3715PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3715PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human HER2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3715PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3715PubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3715PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of human Flt3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3715PubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of human LckMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3715PubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 195nMAssay Description:Inhibition of human LynMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3715PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 156nMAssay Description:Inhibition of human SrcMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26M3715PubMed
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Califia Bio Inc.

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataKd:  700nMAssay Description:Binding affinity to human MLK3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataKd:  3.80nMAssay Description:Binding affinity to human FLT3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P270KSPubMed
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of human VEGFR3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75JSPubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human IGFR1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75JSPubMed
TargetInsulin receptor(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human InsRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75JSPubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75JSPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75JSPubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human HER2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75JSPubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Boehringer Ingelheim Pharma GmbH&Co KG

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Plk1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75JSPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 156nMAssay Description:Inhibition of human SrcMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75JSPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of human Flt3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75JSPubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 195nMAssay Description:Inhibition of human LynMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75JSPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of human LckMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75JSPubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of human PDGFRalphaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75JSPubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 104nMAssay Description:Inhibition of human VEGFR1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75JSPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of human VEGFR2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH

Curated by ChEMBL
LigandPNGBDBM50279080((Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acety...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of PDGFRalpha (unknown origin) using poly (Glu, Tyr)4:1 as substrate by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B27WQ7PubMed