null
SMILES COC(=O)c1ccc2C(C(=Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
InChI Key InChIKey=SWDINMTYJOBJBL-UHFFFAOYSA-N
PDB links: 4 PDB IDs match this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 41 hits for monomerid = 50279080
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
East China University of Science and Technology
Curated by ChEMBL
East China University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of PDGFRbeta (unknown origin) using poly (Glu, Tyr)4:1 as substrate by ELISAMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human insulin receptorMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human VEGFR3More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK1More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK1More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:Inhibition of human VEGFR1More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of human GST-fused VEGFR2 expressed in Sf9 insect cells after 20 mins by scintillation countingMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Mus musculus)
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of mouse GST-fused VEGFR2 expressed in Sf9 insect cells after 20 mins by scintillation countingMore data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
Affinity DataIC50: 69nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of human FGFR2More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 108nMAssay Description:Inhibition of human FGFR3More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 610nMAssay Description:Inhibition of human FGFR4More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 59nMAssay Description:Inhibition of human PDGFRalphaMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
East China University of Science and Technology
Curated by ChEMBL
East China University of Science and Technology
Curated by ChEMBL
Affinity DataIC50: 65nMAssay Description:Inhibition of human PDGFRbetaMore data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human IGF1RMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human HER2More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK2More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK4More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Inhibition of human Flt3More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of human LckMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 195nMAssay Description:Inhibition of human LynMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 156nMAssay Description:Inhibition of human SrcMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Califia Bio Inc.
Curated by ChEMBL
Califia Bio Inc.
Curated by ChEMBL
Affinity DataKd: 700nMAssay Description:Binding affinity to human MLK3More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataKd: 3.80nMAssay Description:Binding affinity to human FLT3More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human VEGFR3More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human IGFR1More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human InsRMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human CDK4More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EGFRMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human HER2More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
Boehringer Ingelheim Pharma GmbH&Co KG
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human Plk1More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 156nMAssay Description:Inhibition of human SrcMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Inhibition of human Flt3More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 195nMAssay Description:Inhibition of human LynMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of human LckMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of human PDGFRalphaMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 104nMAssay Description:Inhibition of human VEGFR1More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human VEGFR2 expressed in Sf9 cellsMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Boehringer Ingelheim Austria GmbH
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of PDGFRalpha (unknown origin) using poly (Glu, Tyr)4:1 as substrate by ELISAMore data for this Ligand-Target Pair