null
SMILES CC(C)C[C@@H]1NC(=O)[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(O)=O)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC1=O)C(C)C
InChI Key InChIKey=VYCMAAOURFJIHD-AOYLRGCGSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 13 hits for monomerid = 50329850
Affinity DataKi: 18nMAssay Description:Affinity against ET A receptorMore data for this Ligand-Target Pair
TargetEndothelin-1 receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataKi: 40nMAssay Description:Ability to inhibit binding of [125I]ET1 to membranes prepared from A10 rat thoracic aorta smooth muscle Endothelin A receptorMore data for this Ligand-Target Pair
Affinity DataKi: 7.00E+3nMAssay Description:Affinity against ET B receptorMore data for this Ligand-Target Pair
Affinity DataKi: 3.20E+4nMAssay Description:Ability to inhibit binding of [125I]-ET-1 to membranes prepared from A10 rat cerebellum (Endothelin B receptor)More data for this Ligand-Target Pair
TargetATP-binding cassette sub-family C member 2(Rattus norvegicus)
University of Tokyo
Curated by ChEMBL
University of Tokyo
Curated by ChEMBL
Affinity DataKi: 8.41E+4nMAssay Description:TP_TRANSPORTER: inhibition of BQ-485 uptake in bile canalicular membrane vesicles from SD ratMore data for this Ligand-Target Pair
TargetEndothelin-1 receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:In vitro inhibition of [125I]ET1 binding to rat A10 cell Endothelin A receptor.More data for this Ligand-Target Pair
TargetEndothelin-1 receptor(RAT)
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Bristol-Myers Squibb Pharmaceutical Research Institute
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibitory concentration towards endothelin A receptor in rat.More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:In vitro inhibition of [125I]ET1 binding to rat cerebellum Endothelin B receptor.More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+4nMAssay Description:Compound was evaluated for the binding affinity to Endothelin B receptor in the porcine cerebellum.More data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin B receptor in porcine cerebellum membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibitory activity against 125 I-labeled ET-1 binding to Endothelin A receptor in porcine aortic smooth muscle membranes.More data for this Ligand-Target Pair
Affinity DataIC50: 24.8nMAssay Description:Displacement of [125I]ET1 from ETA receptor expressed in african green monkey CCL-81 cells monolayerMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+4nMAssay Description:Compound was evaluated for the binding affinity to Endothelin A receptor in the porcine aortic smooth muscleMore data for this Ligand-Target Pair