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SMILES CO[C@@H]1OC[C@@H](O[C@H]1Oc1cc2O[C@]3([C@@H]([C@H]([C@@H](O)[C@@]3(O)c2c(OC)c1)C(=O)OC)c1ccccc1)c1ccc(OC)cc1)[C@H](O)CO

InChI Key InChIKey=GVKXFVCXBFGBCD-QKDMMWSPSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50335583   

TargetTranscription factor p65(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50335583(CHEMBL555196 | silvestrol)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of NFkappaB p65 isolated from nuclear extract of human HeLa cells assessed as blockade of binding to biotinylated consesus sequence by che...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZC833QPubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50335583(CHEMBL555196 | silvestrol)copy SMILEScopy InChI
Affinity DataEC50:  7nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation i...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0V1XPubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Infinity Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50335583(CHEMBL555196 | silvestrol)copy SMILEScopy InChI
Affinity DataEC50:  0.800nMAssay Description:Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0V1XPubMed