null

SMILES COCCN1CCC(CC1)(C(=O)NO)S(=O)(=O)c1ccc(Oc2ccc(OC(F)(F)F)cc2)cc1

InChI Key InChIKey=NXUHVWMBPOFLMA-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50343077   

TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)copy SMILEScopy InChI
Affinity DataKi:  14nMAssay Description:Inhibition of human MMP-14More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2416XCKPubMed
TargetMatrilysin(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)copy SMILEScopy InChI
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition of human MMP-7More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2416XCKPubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human MMP-1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2416XCKPubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of human MMP14 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0NQBPubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human MMP2 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0NQBPubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human MMP13 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0NQBPubMedMMDB
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)copy SMILEScopy InChI
Affinity DataIC50: 0.180nMAssay Description:Inhibition of human MMP9 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0NQBPubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Inhibition of human MMP-3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2416XCKPubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human MMP-8More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2416XCKPubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human MMP8 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0NQBPubMed
TargetMatrilysin(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)copy SMILEScopy InChI
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of human MMP7 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0NQBPubMed
TargetStromelysin-1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Inhibition of human MMP3 assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0NQBPubMed
TargetCollagenase 3(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human MMP-13More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2416XCKPubMedMMDB
TargetInterstitial collagenase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human MMP1 expressed in human HT-1080 cells assessed as cleavage of fluorogenic peptide MCAPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 by fluoromet...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0NQBPubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human MMP-9More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2416XCKPubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50343077(CHEMBL1771212 | N-hydroxy-1-(2-methoxyethyl)-4-(4-...)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Inhibition of human MMP-2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2416XCKPubMed